G
Gergely Talaber
Researcher at University of Pécs
Publications - 17
Citations - 579
Gergely Talaber is an academic researcher from University of Pécs. The author has contributed to research in topics: Glucocorticoid receptor & Phosphorylation. The author has an hindex of 14, co-authored 16 publications receiving 497 citations. Previous affiliations of Gergely Talaber include Karolinska Institutet & State University of New York Upstate Medical University.
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Journal ArticleDOI
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE
Tiffany Caza,David Fernandez,Gergely Talaber,Zachary Oaks,Mark Haas,Michael P. Madaio,Zhi Wei Lai,Gabriella Miklossy,Ram Singh,Dmitriy M. Chudakov,Walter Malorni,Frank A. Middleton,Katalin Banki,Andras Perl +13 more
TL;DR: A pathogenic role for HRES-1/Rab4-mediated Drp1 depletion is revealed and endocytic control of mitophagy is identified as a treatment target in SLE.
Journal ArticleDOI
Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells.
Ferenc Boldizsár,Gergely Talaber,Mariann Szabó,Domokos Bartis,László Pálinkás,Péter Németh,Timea Berki +6 more
TL;DR: The interplay between the T cell receptor (TcR) and glucocorticoid receptor (GR) signalling pathways is described in more detail, focusing on ZAP-70, which is a novel target of rapid GC action.
Journal ArticleDOI
Extra-adrenal glucocorticoid synthesis: immune regulation and aspects on local organ homeostasis
TL;DR: The nature, regulation and known physiological roles of extra-adrenal GC synthesis in the thymus are summarized, in which GC production by both developing thymocytes and epithelial cells has a role in the maintenance of proper immunological function.
Journal ArticleDOI
Mitochondrial translocation of the glucocorticoid receptor in double-positive thymocytes correlates with their sensitivity to glucocorticoid-induced apoptosis
Gergely Talaber,Ferenc Boldizsár,Domokos Bartis,László Pálinkás,Mariann Szabó,Gergely Berta,György Sétáló,Péter Németh,Timea Berki +8 more
TL;DR: The abundant mitochondrial GR found in DP cells well correlates with their high GC-induced apoptosis sensitivity, and it is found that in DX-treated cells a significant fraction of the GR translocates into the mitochondria.
Journal ArticleDOI
Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence
Gergely Talaber,Krisztian Kvell,Zoltan Varecza,Ferenc Boldizsár,Sonia M. Parnell,Eric J. Jenkinson,Graham Anderson,Timea Berki,Judit E. Pongracz +8 more
TL;DR: It is shown that primary thymic epithelial cells (TECs) express glucocorticoid receptors and that high-dosage dexamethasone induces degeneration of the thymi epithelium within 24 h of treatment.