S
Sam Okret
Researcher at Karolinska Institutet
Publications - 112
Citations - 10322
Sam Okret is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Glucocorticoid receptor & Receptor. The author has an hindex of 52, co-authored 110 publications receiving 10120 citations. Previous affiliations of Sam Okret include Norwegian University of Science and Technology & University of California, San Francisco.
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Journal ArticleDOI
Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
Roger L. Miesfeld,Sandro Rusconi,Paul J. Godowski,Bonnie A. Maler,Sam Okret,Ann Charlotte Wikström,Jan-Åke Gustafsson,Keith R. Yamamoto +7 more
TL;DR: The cloned receptor protein activates its corresponding enhancers, restoring to the receptor-deficient cells the full capacity for regulated enhancement.
Journal ArticleDOI
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.
Farhang Payvar,Donald B. DeFranco,Gary L. Firestone,Bruce A. Edgar,Örjan Wrange,Sam Okret,Jan-Åke Gustafsson,Keith R. Yamamoto +7 more
TL;DR: Five regions of MTV DNA that are bound specifically by purified receptor are mapped and compared, suggesting that receptor affinity for upstream and internal regions may differ by less than one order of magnitude.
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Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
Eric Caldenhoven,Johan Liden,Sacha Wissink,A. Van De Stolpe,J. A. M. Raaijmakers,Leo Koenderman,Sam Okret,Jan-Ake Gustafsson,P. T. Van Der Saag +8 more
TL;DR: Evidence is presented that the ligand-activated glucocorticoid receptor (GR) is able to repress RelA-mediated activation of the ICAM-1 NF-kappa B site, which highlights a possible molecular mechanism that can explain the antiinflammatory effects of glucoc Corticoid treatment during inflammation.
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Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor.
Kjell Fuxe,Ann-Charlotte Wikström,Sam Okret,Luigi F. Agnati,Anders Härfstrand,Zhao-Ying Yu,Lars Granholm,Michaeli Zoli,Wylie Vale,Jan-Åke Gustafsson +9 more
TL;DR: It is suggested that the hypothalamic GR may be involved in the regulation of especially CRF secretion but also in the secretion of other anterior pituitary hormones such as TRH and somatostatin.
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Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain
Anders Härfstrand,Kjell Fuxe,Antonio Cintra,L. F. Agnati,Isabella Zini,Ann-Charlotte Wikström,Sam Okret,Zhao-Ying Yu,Menek Goldstein,Harry W.M. Steinbusch +9 more
TL;DR: A monoclonal antibody against the rat liver glucocorticoid receptor was used in combination with rabbit antibodies against tyrosine hydroxylase, phenylethanolamine N-methyltransferase, and 5-hydroxytryptaminergic cell bodies to demonstrate strong glucocortex receptor immunoreactivity in large numbers of central monoaminergic nerve cell bodies of the male rat.