G
Gerhard Schratt
Researcher at ETH Zurich
Publications - 86
Citations - 9099
Gerhard Schratt is an academic researcher from ETH Zurich. The author has contributed to research in topics: microRNA & Dendritic spine. The author has an hindex of 43, co-authored 76 publications receiving 8279 citations. Previous affiliations of Gerhard Schratt include University Hospital Heidelberg & Harvard University.
Papers
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Releasing a tiny molecular brake may improve memory
Roberto Fiore,Gerhard Schratt +1 more
TL;DR: Zovoilis et al. as mentioned in this paper identified miR•34c as a hippocampal-specific microRNA upregulated in ageing and neurodegeneration, which might be both a marker for the onset of memory impairments and a promising target for therapeutic approaches in dementia.
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Non-coding RNA in the wiring and remodeling of neural circuits
TL;DR: In this paper , the potential relevance of ncRNAs for cell-type and -state-specific regulation in the context of memory formation, the evolution of human cognitive abilities, and the development of new diagnostic and therapeutic tools in brain disorders.
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Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism.
Silvia Bicker,Gerhard Schratt +1 more
TL;DR: It is demonstrated that a miRNA-mediated mechanism plays a critical role in learning and memory in vertebrates and expression of this miRNA was discovered to be controlled by sirtuin1 (SIRT1), a histone deacetylase well-known for regulating lifespan.
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Streamlining differential exon and 3' UTR usage with diffUTR.
TL;DR: The diffUTR Bioconductor package as mentioned in this paper leverages existing DEU tools and alternative poly-adenylation site databases to enable differential 3′ UTR usage analysis, which is more flexible and more accurate than state-of-the-art alternatives, both in simulations and in real data.
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The cytoplasmic SYNCRIP mRNA interactome of mammalian neurons.
Sharof Khudayberdiev,Michael Soutschek,Irina Ammann,Anika Heinze,Marco B. Rust,Stefan Baumeister,Gerhard Schratt +6 more
TL;DR: The stabilization of mRNAs encoding for components of the microtubule network, such as doublecortin (Dcx), emerges as a novel mechanism of SYNCRIP function in addition to the previously reported control of actin dynamics.