R
Roberto Fiore
Researcher at University of Marburg
Publications - 13
Citations - 1656
Roberto Fiore is an academic researcher from University of Marburg. The author has contributed to research in topics: Regulation of gene expression & Synaptic scaling. The author has an hindex of 12, co-authored 13 publications receiving 1516 citations. Previous affiliations of Roberto Fiore include University Hospital Heidelberg & Heidelberg University.
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Journal ArticleDOI
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
Gabriele Siegel,Gregor Obernosterer,Roberto Fiore,Martin Oehmen,Silvia Bicker,Mette Christensen,Mette Christensen,Sharof Khudayberdiev,Philipp F Leuschner,Clara J L Busch,Christina G. Kane,Katja Hübel,Frank J. Dekker,Christian Hedberg,Balamurugan Rengarajan,Carsten Drepper,Carsten Drepper,Herbert Waldmann,Sakari Kauppinen,Sakari Kauppinen,Michael E. Greenberg,Andreas Draguhn,Marc Rehmsmeier,Marc Rehmsmeier,Javier Martinez,Gerhard Schratt +25 more
TL;DR: The results uncover a previously unknown miRNA-dependent mechanism in neurons and demonstrate a previously unrecognized complexity of mi RNA-dependent control of dendritic spine morphogenesis.
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Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
Roberto Fiore,Sharof Khudayberdiev,Mette Christensen,Mette Christensen,Gabriele Siegel,Steven W. Flavell,Tae Kyung Kim,Michael E. Greenberg,Gerhard Schratt +8 more
TL;DR: A novel regulatory pathway is described that couples activity‐dependent transcription to miRNA‐dependent translational control of gene expression during neuronal development and promotes outgrowth of hippocampal neurons.
Journal ArticleDOI
MicroRNA function in neuronal development, plasticity and disease.
TL;DR: The development and function of the nervous system is orchestrated by a plethora of gene regulatory mechanisms, and miRNAs are emerging as important post-transcriptional regulators of gene expression in the brain.
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Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
Giordano Lippi,Joern R. Steinert,Emma L. Marczylo,Sabina D’Oro,Roberto Fiore,Ian D. Forsythe,Gerhard Schratt,Michele Zoli,Pierluigi Nicotera,Kenneth W. Young +9 more
TL;DR: In this article, the authors identified Arpc3, a component of the ARP2/3 actin nucleation complex, as a bona fide target for down-regulation by miR-29a/b.
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A coding-independent function of an alternative Ube3a transcript during neuronal development
Jeremy Valluy,Silvia Bicker,Ayla Aksoy-Aksel,Martin Lackinger,Simon Sumer,Roberto Fiore,Tatjana Wüst,Dominik Seffer,Franziska Metge,Christoph Dieterich,Markus Wöhr,Rainer K.W. Schwarting,Gerhard Schratt +12 more
TL;DR: Ube3a1 RNA, a transcript that encodes a truncated U be3a protein lacking catalytic activity, prevents exuberant dendrite growth and promotes spine maturation in rat hippocampal neurons and defines a noncoding function of an alternative Ube3A transcript in dendritic protein synthesis, with potential implications for Angelman syndrome and ASD.