Gerti Stange

TL;DR: It is concluded that the structurally identified two closely related proteins most likely involved in human and rat renal brush border Na/Pi cotransport.

TL;DR: It is reported that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney.

TL;DR: A cDNA clone is isolated by screening a rabbit kidney cortex cDNA library for expression of sodium-independent transport of L-arginine and L-alanine in Xenopus laevis oocytes and relates to a single component of Sodium- independent transport for dibasic and neutral amino acids.

TL;DR: Analysis by subcellular fractionation and morphological techniques showed that the Na/Pi cotransporter is constitutively transported to and degraded within late endosomes/lysosomes and that PTH leads to the increased degradation of the transporter in late endo-lysosome.

TL;DR: It is shown that a member of the SLC20 gene family (PiT-2) is localized to the brush-border membrane (BBM) of the PT epithelia and that its abundance, confirmed by Western blot and immunohistochemistry of rat kidney slices, is regulated by dietary P(i).