J
J. Andrew Pospisilik
Researcher at Max Planck Society
Publications - 55
Citations - 5767
J. Andrew Pospisilik is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 30, co-authored 38 publications receiving 5056 citations. Previous affiliations of J. Andrew Pospisilik include University of British Columbia & Institute of Molecular Biotechnology.
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Journal ArticleDOI
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
Arvand Haschemi,Arvand Haschemi,Paul Kosma,Lars Gille,Charles R. Evans,Charles F. Burant,Philipp Starkl,Bernhard Knapp,Robert Haas,Johannes A. Schmid,Christoph Jandl,Shahzada Amir,Gert Lubec,Jaehong Park,Harald Esterbauer,Martin Bilban,Leonardo Brizuela,J. Andrew Pospisilik,Leo E. Otterbein,Oswald Wagner +19 more
TL;DR: It is found that CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and a rate-limiting requirement for appropriate glucose flux in macrophages polarization is uncovered.
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A new fate mapping system reveals context-dependent random or clonal expansion of microglia
Tuan Leng Tay,Dominic Mai,Jana Dautzenberg,Francisco Fernández-Klett,Gen Lin,Sagar,Moumita Datta,Anne Drougard,Thomas Stempfl,Alberto Ardura-Fabregat,Ori Staszewski,Anca Margineanu,Anje Sporbert,Lars M. Steinmetz,J. Andrew Pospisilik,Steffen Jung,Josef Priller,Josef Priller,Dominic Grün,Olaf Ronneberger,Marco Prinz +20 more
TL;DR: The dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS is unravels and a new multicolor fluorescence fate mapping system is established to monitor microglial dynamics during steady state and disease.
Journal ArticleDOI
Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes
J. Andrew Pospisilik,Claude Knauf,Nicholas Joza,Paule Bénit,Michael Orthofer,Patrice D. Cani,Patrice D. Cani,Ingo Ebersberger,Tomoki Nakashima,Renu Sarao,G. Greg Neely,Harald Esterbauer,Andrey V. Kozlov,C. Ronald Kahn,Guido Kroemer,Guido Kroemer,Guido Kroemer,Pierre Rustin,Rémy Burcelin,Josef M. Penninger +19 more
TL;DR: It is shown that muscle- and liver-specific AIF ablation in mice initiates a pattern of OxPhos deficiency closely mimicking that of human insulin resistance, and contrary to current expectations, results in increased glucose tolerance, reduced fat mass, and increased insulin sensitivity.
Journal ArticleDOI
Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
J. Andrew Pospisilik,Jennifer Martin,Timothy Doty,Jan A. Ehses,Nathalie Pamir,Francis C. Lynn,Shalea Piteau,Hans-Ulrich Demuth,Christopher H.S. McIntosh,Raymond A. Pederson +9 more
TL;DR: In vitro studies using a β-(INS-1) cell line showed a dose-dependent prevention of STZ-induced apoptotic cell-death by both GIP and GLP-1, supporting a role for the incretins in eliciting the in vivo results.
Journal ArticleDOI
Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate
J. Andrew Pospisilik,Daniel Schramek,Harald Schnidar,Shane J. F. Cronin,Nadine T. Nehme,Xiaoyun Zhang,Claude Knauf,Patrice D. Cani,Karin Aumayr,Jelena Todoric,Martina Bayer,Arvand Haschemi,Vijitha Puviindran,Krisztina Tar,Michael Orthofer,G. Gregory Neely,Georg Dietzl,Armen S. Manoukian,Martin Funovics,Gerhard Prager,Oswald Wagner,Dominique Ferrandon,Fritz Aberger,Chi-chung Hui,Harald Esterbauer,Josef M. Penninger +25 more
TL;DR: A role for hedgehog signaling in white/brown adipocyte determination is identified and in vivo RNAi-based scanning of the Drosophila genome is linked to regulation of adipocyte cell fate in mammals.