G
Gertraud Krähn
Researcher at University of Ulm
Publications - 30
Citations - 2371
Gertraud Krähn is an academic researcher from University of Ulm. The author has contributed to research in topics: Melanoma & Metastasis. The author has an hindex of 18, co-authored 30 publications receiving 2268 citations. Previous affiliations of Gertraud Krähn include University of California, Los Angeles & University of California, San Diego.
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Journal ArticleDOI
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Uwe Senftleben,Yixue Cao,Gutian Xiao,Florian R. Greten,Gertraud Krähn,Giuseppina Bonizzi,Yi Chen,Yinling Hu,Abraham Fong,Shao Cong Sun,Michael Karin +10 more
TL;DR: It is shown that IKKα is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-κB target genes, and processing of the NF-σκB2 (p100) precursor.
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Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma
TL;DR: Results strongly indicate that b cl-2 and bcl-xL gene expression increases with progression of malignant melanoma, which could reflect an increased malignant potential caused by an inhibition of apoptosis and growth advantage for metastatic melanoma cells.
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Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia.
Jochen Greiner,Mark Ringhoffer,Masanori Taniguchi,Anita Schmitt,Dieter Kirchner,Gertraud Krähn,Volker Heilmann,Jürgen E. Gschwend,Lothar Bergmann,Hartmut Döhner,Michael Schmitt +10 more
TL;DR: RHAMM is an immunogenic antigen in leukemias and solid tumors and might be a potential target structure for cellular immunotherapies and antibody therapies.
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Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases.
TL;DR: The results suggest that overexpression of the EGFR gene might play an important role in metastasis of malignant melanoma, well reflected by polysomy 7, possibly accounting for an increased EGfr gene copy number.
Journal Article
S100 beta is a more reliable tumor marker in peripheral blood for patients with newly occurred melanoma metastases compared with MIA, albumin and lactate-dehydrogenase.
TL;DR: Evaluated tumor markers S100 in peripheral blood as compared to MIA, LDH and albumin appears to be the most appropriate tumor marker for newly occurred melanoma metastases.