U
Uwe Senftleben
Researcher at University of California, San Diego
Publications - 6
Citations - 2242
Uwe Senftleben is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & IκB kinase. The author has an hindex of 6, co-authored 6 publications receiving 2146 citations. Previous affiliations of Uwe Senftleben include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Uwe Senftleben,Yixue Cao,Gutian Xiao,Florian R. Greten,Gertraud Krähn,Giuseppina Bonizzi,Yi Chen,Yinling Hu,Abraham Fong,Shao Cong Sun,Michael Karin +10 more
TL;DR: It is shown that IKKα is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-κB target genes, and processing of the NF-σκB2 (p100) precursor.
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Requirement for p38α in Erythropoietin Expression
TL;DR: In this paper, a role for p38α in mouse development and physiology was investigated by targeted disruption of the P38α locus, and it was shown that p38−− embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoietin (Epo) gene expression.
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IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis
TL;DR: Almost normal development of IKKβ −/− T cells is observed upon removal of type 1 TNFα receptor, indicating that TNF α signaling accounts for the absence of Ikkβ −-/−T cells.
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Effects of intravenous fat emulsions on lung function in patients with acute respiratory distress syndrome or sepsis.
Ulrich Suchner,D.P. Katz,Peter Fürst,Klaus Beck,Thomas W. Felbinger,Uwe Senftleben,Manfred Thiel,Alwin E. Goetz,Klaus Peter +8 more
TL;DR: Pulmonary hemodynamics and gas exchange are related to changes of arterial prostanoid levels in ARDS patients, depending on the rate of fat infusion, and a changing balance of prostaglandin I2 and thromboxane A2 may modulate gas exchange.