G
Gevorg Grigoryan
Researcher at Dartmouth College
Publications - 68
Citations - 3010
Gevorg Grigoryan is an academic researcher from Dartmouth College. The author has contributed to research in topics: Protein structure & Protein Data Bank. The author has an hindex of 23, co-authored 58 publications receiving 2453 citations. Previous affiliations of Gevorg Grigoryan include Massachusetts Institute of Technology & University of Pennsylvania.
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Journal ArticleDOI
Design of protein-interaction specificity gives selective bZIP-binding peptides.
TL;DR: A computational framework for designing protein-interaction specificity is presented and used to identify specific peptide partners for human basic-region leucine zipper (bZIP) transcription factors and may prove broadly useful as a tool for protein design.
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Structural specificity in coiled-coil interactions
Gevorg Grigoryan,Amy E. Keating +1 more
TL;DR: Experimental and computational methods for dealing with the near-degeneracy of many coiled-coil structures appear promising for future design applications.
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De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Nathan H. Joh,Tuo Wang,Manasi P. Bhate,Rudresh Acharya,Yibing Wu,Michael Grabe,Mei Hong,Gevorg Grigoryan,William F. DeGrado +8 more
TL;DR: A membrane-spanning, four-helical bundle that transports first-row transition metal ions Zn2+ and Co2+, but not Ca2+, across membranes is reported, which illustrates the feasibility of designing membrane proteins with predefined structural and dynamic properties.
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Probing Designability via a Generalized Model of Helical Bundle Geometry
TL;DR: A general mathematical framework for parameterizing arbitrary helical structures, which reduces to the Crick parameterization as a special case, is developed and successfully validated on a set of non-coiled-coil helical bundles, which show significant helix bending but not supercoiling.
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Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces
Gevorg Grigoryan,Yong Ho Kim,Rudresh Acharya,Kevin Axelrod,Rishabh M. Jain,Lauren J. Willis,Marija Drndic,James M. Kikkawa,William F. DeGrado +8 more
TL;DR: A computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides is described, exemplifying the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes.