G
Giancarlo V. De Ferrari
Researcher at Andrés Bello National University
Publications - 36
Citations - 2895
Giancarlo V. De Ferrari is an academic researcher from Andrés Bello National University. The author has contributed to research in topics: Wnt signaling pathway & Beta-catenin. The author has an hindex of 17, co-authored 36 publications receiving 2684 citations. Previous affiliations of Giancarlo V. De Ferrari include University of Washington & University of Chile.
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Journal ArticleDOI
WNT and β-catenin signalling: diseases and therapies
TL;DR: WNT signalling has been studied primarily in developing embryos, but WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer.
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Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease
Giancarlo V. De Ferrari,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Travis L. Biechele,Fabienne Wavrant DeVrieze,Miguel E. Avila,Michael B. Major,Amanda J. Myers,Katia Sáez,Juan Pablo Henríquez,Alice Zhao,M. Axel Wollmer,Roger M. Nitsch,Christoph Hock,Christopher Morris,John Hardy,Randall T. Moon +16 more
TL;DR: The study unveils a genetic relationship between LRP6 and APOE and supports the hypothesis that altered Wnt/β-catenin signaling may be involved in this neurodegenerative disease.
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Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites
Giancarlo V. De Ferrari,William D. Mallender,William D. Mallender,Nibaldo C. Inestrosa,Terrone L. Rosenberry +4 more
TL;DR: Thioflavin T, a fluorophore widely used to detect amyloid structure in proteins, binds selectively to the AChE peripheral site with an equilibrium dissociation constant of 1.0 μm, providing strong evidence in support of a conformational interaction between the two A cholinesterase sites.
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Wnt/β-Catenin Signaling Enhances Cyclooxygenase-2 (COX2) Transcriptional Activity in Gastric Cancer Cells
TL;DR: A novel functional T-cell factor/lymphoid enhancer factor (TCF/LEF)-response element that responds directly to enhanced Wnt/β-catenin signaling and which may be important for the onset/progression of GC is concluded.
Journal ArticleDOI
Wnt signaling involvement in β-amyloid-dependent neurodegeneration
Nibaldo C. Inestrosa,Giancarlo V. De Ferrari,Jose Luis Garrido,Alejandra R. Alvarez,Gonzalo H. Olivares,María Inés Barría,Miguel Bronfman,Marcelo A. Chacón +7 more
TL;DR: It has been observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects.