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Ajamete Kaykas
Researcher at Novartis
Publications - 44
Citations - 6768
Ajamete Kaykas is an academic researcher from Novartis. The author has contributed to research in topics: Wnt signaling pathway & Induced pluripotent stem cell. The author has an hindex of 25, co-authored 39 publications receiving 5788 citations. Previous affiliations of Ajamete Kaykas include Allen Institute for Brain Science & Howard Hughes Medical Institute.
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Journal ArticleDOI
WNT and β-catenin signalling: diseases and therapies
TL;DR: WNT signalling has been studied primarily in developing embryos, but WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer.
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Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
TL;DR: The results support the idea that a vertebrate PCP pathway regulates gastrulation movements and suggest that there is overlap between the PCP and Wnt/calcium pathways.
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p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
Robert J. Ihry,Kathleen A. Worringer,Max R. Salick,Elizabeth Frias,Daniel J. Ho,Kraig M. Theriault,Sravya Kommineni,Julie Chen,Marie Sondey,Chaoyang Ye,Ranjit Randhawa,Tripti Kulkarni,Zinger Yang,Gregory McAllister,Carsten Russ,John S. Reece-Hoyes,William C. Forrester,Gregory R. Hoffman,Ricardo E. Dolmetsch,Ajamete Kaykas +19 more
TL;DR: The results indicate that Cas9 toxicity creates an obstacle to the high-throughput use of CRISPR/Cas9 for genome engineering and screening in hPSCs, and as h PSCs can acquire P53 mutations14, cell replacement therapies using CRISpr/cas9-enginereed hPSCS should proceed with caution, and such engineered hPSPs should be monitored for P53 function.
Journal ArticleDOI
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Johane M Robitaille,Marcia L.E. MacDonald,Ajamete Kaykas,Laird C. Sheldahl,J Zeisler,Marie-Pierre Dubé,Lin-Hua Zhang,Roshni R. Singaraja,Duane L. Guernsey,B. Zheng,Lee Siebert,A. Hoskin-Mott,Michael T. Trese,Simon N. Pimstone,Barkur S. Shastry,Randall T. Moon,Michael R. Hayden,Y. Paul Goldberg,Mark E. Samuels +18 more
TL;DR: Injection of wildtype and mutated FZD4 into Xenopus laevis embryos revealed that wildtype, but not mutant, frizzled-4 activated calcium/calmodulin-dependent protein kinase II andprotein kinase C, components of the Wnt/Ca2+ signaling pathway.
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Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Carl M. Sellgren,Jessica Gracias,Jessica Gracias,Bradley Watmuff,Jonathan D. Biag,Jessica M. Thanos,Paul B. Whittredge,Ting Fu,Kathleen A. Worringer,Hannah E. Brown,Jennifer P. Wang,Ajamete Kaykas,Rakesh Karmacharya,Rakesh Karmacharya,Carleton Goold,Steven D. Sheridan,Roy H. Perlis +16 more
TL;DR: It is demonstrated that the antibiotic minocycline reduces microglia-mediated synapse uptake in vitro and its use is associated with a modest decrease in incident schizophrenia risk compared to other antibiotics in a cohort of young adults drawn from electronic health records.