G
Gianluca Matteoli
Researcher at Katholieke Universiteit Leuven
Publications - 96
Citations - 4750
Gianluca Matteoli is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 29, co-authored 84 publications receiving 3687 citations. Previous affiliations of Gianluca Matteoli include University of Tübingen & European Institute of Oncology.
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Journal ArticleDOI
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells
Iliyan D. Iliev,Ilaria Spadoni,Erika Mileti,Gianluca Matteoli,Angelica Sonzogni,Gianluca M. Sampietro,Diego Foschi,Flavio Caprioli,Giuseppe Viale,Maria Rescigno +9 more
TL;DR: A population of tolerogenic CD103+ DCs was identified in the human gut that probably differentiate in response to IEC-derived factors and drive Treg cell development.
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Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
TL;DR: A deeper understanding of the molecular pathways involved in the differentiation and functions of intestinal macrophages might lead to a new class of targets to promote remission in patients with IBD.
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Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
TL;DR: Evidence is presented that the local microenvironment, and in particular intestinal epithelial cells (ECs), drive the differentiation of Treg-cell-promoting DCs, which counteracts Th1 and Th17 development.
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Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
Gianluca Matteoli,Elisa Mazzini,Iliyan D. Iliev,Erika Mileti,Francesca Fallarino,Paolo Puccetti,Marcello Chieppa,Maria Rescigno +7 more
TL;DR: A new IDO-dependent pathway leading to acquisition of tolerogenic functions in mucosal CD103-expressing DCs is identified, indicating IDO as a possible therapeutic target for gut disorders.
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A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
Gianluca Matteoli,Pedro J. Gomez-Pinilla,Andrea Nemethova,Martina Di Giovangiulio,Cathy Cailotto,Sjoerd H. van Bree,Klaus Michel,Kevin J. Tracey,Michael Schemann,Werend Boesmans,Pieter Vanden Berghe,Guy E. Boeckxstaens +11 more
TL;DR: It is shown that the anti-inflammatory effect of the VNS in the intestine is independent of the spleen and T cells, and intestinal muscularis resident macrophages expressing α7nAChR are most likely the ultimate target of the gastrointestinal CAIP.