M
Michael Schemann
Researcher at Technische Universität München
Publications - 242
Citations - 10690
Michael Schemann is an academic researcher from Technische Universität München. The author has contributed to research in topics: Enteric nervous system & Myenteric plexus. The author has an hindex of 54, co-authored 230 publications receiving 9578 citations. Previous affiliations of Michael Schemann include University of Hohenheim & University of Hamburg.
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Journal ArticleDOI
Irritable bowel syndrome
Paul Enck,Qasim Aziz,Giovanni Barbara,Adam D. Farmer,Shin Fukudo,Emeran A. Mayer,Beate Niesler,Eamonn Martin Quigley,Mirjana Rajilić-Stojanović,Michael Schemann,Juliane Schwille-Kiuntke,Magnus Simren,Stephan Zipfel,Robin C. Spiller +13 more
TL;DR: The past decade has seen remarkable progress in the understanding of functional bowel disorders such as IBS that will be summarized in this Primer.
Journal ArticleDOI
The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
Tamira K. Klooker,Breg Braak,Karin E. Koopman,Olaf Welting,Mira M. Wouters,Sicco van der Heide,Michael Schemann,Stephan C. Bischoff,Rene M. van den Wijngaard,Guy Boeckxstaens,Guy Boeckxstaens +10 more
TL;DR: This study shows that ketotifen increases the threshold for discomfort in patients with IBS with visceral hypersensitivity, reduces IBS symptoms and improves health-related quality of life.
Journal ArticleDOI
A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
Gianluca Matteoli,Pedro J. Gomez-Pinilla,Andrea Nemethova,Martina Di Giovangiulio,Cathy Cailotto,Sjoerd H. van Bree,Klaus Michel,Kevin J. Tracey,Michael Schemann,Werend Boesmans,Pieter Vanden Berghe,Guy E. Boeckxstaens +11 more
TL;DR: It is shown that the anti-inflammatory effect of the VNS in the intestine is independent of the spleen and T cells, and intestinal muscularis resident macrophages expressing α7nAChR are most likely the ultimate target of the gastrointestinal CAIP.
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Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome
Sabine Buhner,Q Li,Sheila Vignali,Giovanni Barbara,Roberto De Giorgio,Vincenzo Stanghellini,Cesare Cremon,Florian Zeller,Rupert Langer,Hannelore Daniel,Klaus Michel,Michael Schemann +11 more
TL;DR: Mediators released from mucosal biopsies of IBS patients can activate human submucosal neurons and altered signaling between mucosa and the enteric nervous system might be involved in IBS pathogenesis.
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Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man
Holger Klapproth,Torsten Reinheimer,Jürgen Metzen,Michael Münch,Ferdinand Bittinger,Charles James Kirkpatrick,Karl-Dieter Höhle,Michael Schemann,Kurt Racké,Ignaz Wessler +9 more
TL;DR: The present experiments demonstrate a widespread existence of non-neuronal acetylcholine in surface cells of man and may act as a local signalling molecule.