Gilles Ponchel

TL;DR: The present review focuses on the gastrointestinal bioadhesion of micro- and nanoparticles in the gastrointestinal tract, and proposes a strategy to associate drugs to polymeric nanoparticulate systems because of their propensity to interact with the mucosal surface.

TL;DR: Improved interpenetration ability with the mucus chain during the attachment process was suggested for the chitosan of high molecular weight, enhancing the bioadhesiveness of the system.

TL;DR: In this article, a modified tensile tester in contact with bovine sublingual mucus, and the force-elongation behavior was measured up to the breakpoint was calculated and related to bioadhesive characteristics of the tablets.

TL;DR: Two new possibilities of using cyclodextrins in the design of colloidal carriers are presented, one of which consists in increasing the loading capacity of poly(isobutyl cyanoacrylate) nanospheres prepared by anionic polymerization, and the other in the spontaneous formation of either nanocapsules or Nanospheres by the nanoprecipitation of amphiphiliccyclodextrin diesters.

TL;DR: The therapeutic potential of colloidal drug carriers after oral administration is probably not to deliver the drug directly into the blood flow but to increase bioavailability by protecting the drug from denaturation in the gastro-intestinal lumen, or by increasing the drug concentration for a prolonged period of time directly at the surface of the mucous membrane.