G
Ginés M. Salido
Researcher at University of Extremadura
Publications - 282
Citations - 7658
Ginés M. Salido is an academic researcher from University of Extremadura. The author has contributed to research in topics: Thapsigargin & Intracellular. The author has an hindex of 44, co-authored 272 publications receiving 6952 citations. Previous affiliations of Ginés M. Salido include University of Granada.
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Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores.
TL;DR: It is described for the first time that Ca2+ store depletion stimulates rapid STIM1 surface expression and association with endogenously expressed human canonical TRP1 (hTRPC1) independently of rises in cytosolic free Ca 2+ concentration.
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Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels.
TL;DR: Evidence is presented for the dynamic interaction between endogenously expressed Orai1 and both STIM1 and hTRPC1 regulated by depletion of the intracellular Ca2+ stores, using the pharmacological tools thapsigargin plus ionomycin, or by the physiological agonist thrombin.
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TRPC channels and store-operated Ca2+ entry
TL;DR: This review attempts to provide an overview of the arguments in favour and against the role of TRPC proteins in the store-operated mechanisms of agonist-activated Ca(2+) entry.
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Hydrogen Peroxide Generation Induces pp60src Activation in Human Platelets EVIDENCE FOR THE INVOLVEMENT OF THIS PATHWAY IN STORE-MEDIATED CALCIUM ENTRY
Juan A. Rosado,Pedro C. Redondo,Ginés M. Salido,Emilio Gomez-Arteta,Stewart O. Sage,José A. Pariente +5 more
TL;DR: It is suggested that platelet activation with TG plus Iono or thrombin is associated with H2O2 production, which acts as a second messenger by stimulating pp60src by a PKC-dependent pathway and is involved in the activation of SMCE in these cells.
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Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets
TL;DR: The results indicate that thrombin‐induced apoptosis is likely mediated by endogenous generation of H2O2 in human platelets.