Showing papers by "Giorgio Conti published in 2000"
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TL;DR: The results of this prospective randomized study indicate that transplantation programs should consider NIV in the treatment of selected recipients of transplantation with acute respiratory failure.
Abstract: ContextNoninvasive ventilation (NIV) has been associated with lower rates of
endotracheal intubation in populations of patients with acute respiratory
failure.ObjectiveTo compare NIV with standard treatment using supplemental oxygen administration
to avoid endotracheal intubation in recipients of solid organ transplantation
with acute hypoxemic respiratory failure.Design and SettingProspective randomized study conducted at a 14-bed, general intensive
care unit of a university hospital.PatientsOf 238 patients who underwent solid organ transplantation from December
1995 to October 1997, 51 were treated for acute respiratory failure. Of these,
40 were eligible and 20 were randomized to each group.InterventionNoninvasive ventilation vs standard treatment with supplemental oxygen
administration.Main Outcome MeasuresThe need for endotracheal intubation and mechanical ventilation at any
time during the study, complications not present on admission, duration of
ventilatory assistance, length of hospital stay, and intensive care unit mortality.ResultsThe 2 groups were similar at study entry. Within the first hour of treatment,
14 patients (70%) in the NIV group, and 5 patients (25%) in the standard treatment
group improved their ratio of the PaO2 to the fraction of inspired
oxygen (FIO2). Over time, a sustained improvement in PaO2 to FIO2 was noted in 12 patients (60%) in the NIV group,
and in 5 patients (25%) randomized to standard treatment (P = .03). The use of NIV was associated with a significant reduction
in the rate of endotracheal intubation (20% vs 70%; P
= .002), rate of fatal complications (20% vs 50%; P
= .05), length of stay in the intensive care unit by survivors (mean [SD]
days, 5.5 [3] vs 9 [4]; P = .03), and intensive care
unit mortality (20% vs 50%; P = .05). Hospital mortality
did not differ.ConclusionsThese results indicate that transplantation programs should consider
NIV in the treatment of selected recipients of transplantation with acute
respiratory failure.
684 citations
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TL;DR: Despite early physiologic improvement, CPAP neither reduced the need for intubation nor improved outcomes in patients with acute hypoxemic, nonhypercapnic respiratory insufficiency primarily due to acute lung injury.
Abstract: ContextContinuous positive airway pressure (CPAP) is widely used in the belief
that it may reduce the need for intubation and mechanical ventilation in patients
with acute hypoxemic respiratory insufficiency.ObjectiveTo compare the physiologic effects and the clinical efficacy of CPAP
vs standard oxygen therapy in patients with acute hypoxemic, nonhypercapnic
respiratory insufficiency.Design, Setting, and PatientsRandomized, concealed, and unblinded trial of 123 consecutive adult
patients who were admitted to 6 intensive care units between September 1997
and January 1999 with a PaO2/FIO2 ratio of 300 mm Hg
or less due to bilateral pulmonary edema (n = 102 with acute lung injury and
n = 21 with cardiac disease).InterventionsPatients were randomly assigned to receive oxygen therapy alone (n =
61) or oxygen therapy plus CPAP (n = 62).Main Outcome MeasuresImprovement in PaO2/FIO2 ratio, rate of endotracheal
intubation at any time during the study, adverse events, length of hospital
stay, mortality, and duration of ventilatory assistance, compared between
the CPAP and standard treatment groups.ResultsAmong the CPAP vs standard therapy groups, respectively, causes of respiratory
failure (pneumonia, 54% and 55%), presence of cardiac disease (33% and 35%),
severity at admission, and hypoxemia (median [5th-95th percentile] PaO2/FIO2 ratio, 140 [59-288] mm Hg vs 148 [62-283] mm Hg; P = .43) were similarly distributed. After 1 hour of treatment,
subjective responses to treatment (P<.001) and
median (5th-95th percentile) PaO2/FIO2 ratios were greater
with CPAP (203 [45-431] mm Hg vs 151 [73-482] mm Hg; P
= .02). No further difference in respiratory indices was observed between
the groups. Treatment with CPAP failed to reduce the endotracheal intubation
rate (21 [34%] vs 24 [39%] in the standard therapy group; P = .53), hospital mortality (19 [31%] vs 18 [30%]; P = .89), or median (5th-95th percentile) intensive care unit length
of stay (6.5 [1-57] days vs 6.0 [1-36] days; P =
.43). A higher number of adverse events occurred with CPAP treatment (18 vs
6; P = .01).ConclusionIn this study, despite early physiologic improvement, CPAP neither reduced
the need for intubation nor improved outcomes in patients with acute hypoxemic,
nonhypercapnic respiratory insufficiency primarily due to acute lung injury.
457 citations
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TL;DR: In this paper, the authors compared NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of solid organ transplantation with acute hypoxemic respiratory failure.
Abstract: CONTEXT
Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure.
OBJECTIVE
To compare NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of solid organ transplantation with acute hypoxemic respiratory failure.
DESIGN AND SETTING
Prospective randomized study conducted at a 14-bed, general intensive care unit of a university hospital.
PATIENTS
Of 238 patients who underwent solid organ transplantation from December 1995 to October 1997, 51 were treated for acute respiratory failure. Of these, 40 were eligible and 20 were randomized to each group.
INTERVENTION
Noninvasive ventilation vs standard treatment with supplemental oxygen administration.
MAIN OUTCOME MEASURES
The need for endotracheal intubation and mechanical ventilation at any time during the study, complications not present on admission, duration of ventilatory assistance, length of hospital stay, and intensive care unit mortality.
RESULTS
The 2 groups were similar at study entry. Within the first hour of treatment, 14 patients (70%) in the NIV group, and 5 patients (25%) in the standard treatment group improved their ratio of the PaO2 to the fraction of inspired oxygen (FIO2). Over time, a sustained improvement in PaO2 to FIO2 was noted in 12 patients (60%) in the NIV group, and in 5 patients (25%) randomized to standard treatment (P = .03). The use of NIV was associated with a significant reduction in the rate of endotracheal intubation (20% vs 70%; P = .002), rate of fatal complications (20% vs 50%; P = .05), length of stay in the intensive care unit by survivors (mean [SD] days, 5.5 [3] vs 9 [4]; P = .03), and intensive care unit mortality (20% vs 50%; P = .05). Hospital mortality did not differ.
CONCLUSIONS
These results indicate that transplantation programs should consider NIV in the treatment of selected recipients of transplantation with acute respiratory failure.
105 citations
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TL;DR: Evidence suggests that, before eventual endotracheal intubation, NPPV should be considered as first-line intervention in the early phases of acute exacerbation of chronic obstructive pulmonary disease.
Abstract: Our current state of knowledge on noninvasive positive pressure ventilation (NPPV) and technical aspects are discussed in the present review. In patients with chronic obstructive pulmonary disease, NPPV can be considered a valid therapeutic option to prevent endotracheal intubation. Evidence suggests that, before eventual endotracheal intubation, NPPV should be considered as first-line intervention in the early phases of acute exacerbation of chronic obstructive pulmonary disease. Small randomized and non-randomized studies on the application of NPPV in patients with acute hypoxaemic respiratory failure showed promising results, with reduction in complications such as sinusitis and ventilator-associated pneumonia, and in the duration of intensive care unit stay. The conventional use of NPPV in hypoxaemic acute respiratory failure still remains controversial, however. Large randomized studies are still needed before extensive clinical application in this condition.
29 citations
01 Feb 2000
22 citations
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TL;DR: A trial of NIV could be recommended in the early phases of acute exacerbation of chronic obstructive pulmonary disease, before eventual intubation, to propose noninvasive ventilation as a possible first line intervention for acute hypoxemic respiratory failure.
Abstract: Current knowledge regarding noninvasive ventilation (NIV) and some technical aspects of the subject are discussed. In patients with chronic obstructive pulmonary disease, NIV can prevent endotracheal intubation and reduce mortality. A trial of NIV could be recommended in the early phases of acute exacerbation of chronic obstructive pulmonary disease, before eventual intubation. Some promising preliminary results propose noninvasive ventilation as a possible first line intervention for acute hypoxemic respiratory failure. However, the use of noninvasive ventilation in patients with acute respiratory failure still remains controversial. Large randomized multicenter studies are still needed before extensive clinical application of NIV is used in patients with acute hypoxemic respiratory failure.
20 citations
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2 citations
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TL;DR: The authors review the main systems used in the clinical setting to condition inspiratory gases during mechanical ventilation to describe the functional principles of hot water humidifiers and heat and moisture exchangers.
Abstract: The authors review the main systems used in the clinical setting to condition inspiratory gases during mechanical ventilation. More in details, the functional principles of hot water humidifiers and heat and moisture exchangers are described.
1 citations