G
Giorgio Roma
Researcher at University of Genoa
Publications - 78
Citations - 1551
Giorgio Roma is an academic researcher from University of Genoa. The author has contributed to research in topics: Pyran & Bicyclic molecule. The author has an hindex of 20, co-authored 78 publications receiving 1485 citations.
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1,8-Naphthyridines IV. 9-Substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities
TL;DR: Several compounds 8 exhibited high anti-inflammatory activity (carrageenin-induced paw edema assay in the rat) along with appreciable anti-aggressive properties (isolation-induced aggressiveness test in mice) and the structure-activity relationships are discussed.
Journal ArticleDOI
1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues.
Mario Di Braccio,Giancarlo Grossi,Giorgio Roma,Laura Vargiu,Massimo Mura,Maria Elena Marongiu +5 more
TL;DR: The modifications introduced into nevirapine heterocyclic skeleton proved to have a negative effect for the anti-HIV-1 activity and some of the new derivatives proved to be cytotoxic in the low micromolar range.
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1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity.
Giorgio Roma,Giancarlo Grossi,Mario Di Braccio,Daniela Piras,Vigilio Ballabeni,Massimiliano Tognolini,Simona Bertoni,Elisabetta Barocelli +7 more
TL;DR: Ten compounds designed to obtain new effective analgesic and/or anti-inflammatory agents were synthesized and showed an interesting analgesic activity and two showed notable anti- inflammation properties.
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1,5-Benzodiazepines: Part XIII. Substituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo[1,2-a][1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity
Giancarlo Grossi,Mario Di Braccio,Giorgio Roma,Vigilio Ballabeni,Massimiliano Tognolini,Francesco Calcina,Elisabetta Barocelli +6 more
TL;DR: The 5-(dibutylamino) derivatives 5b and 5f proved to be significantly endowed with all these activities and almost all the compounds 3, 4 and 5 did not show acute toxicity in mice up to 800 mg kg(-1) os dose.
Journal ArticleDOI
Coumarin, chromone, and 4(3H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis
Giorgio Roma,Mario Di Braccio,Antonio Carrieri,Giancarlo Grossi,Giuliana Leoncini,Maria Grazia Signorello,Angelo Carotti +6 more
TL;DR: In order to consider also the 4-aminocoumarin structural class, a new statistically significant 3-D QSAR model is developed based on the antiplatelet activity data and molecular steric and electrostatic potentials of both the previously studied and herein described compounds.