G
Giovanna Leoni
Researcher at Ludwig Maximilian University of Munich
Publications - 35
Citations - 2171
Giovanna Leoni is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Intestinal mucosa & Inflammation. The author has an hindex of 22, co-authored 35 publications receiving 1720 citations. Previous affiliations of Giovanna Leoni include Emory University & Queen Mary University of London.
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Journal ArticleDOI
Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
Giovanna Leoni,Philipp-Alexander Neumann,Nazila Kamaly,Miguel Quiros,Hikaru Nishio,Hefin R. Jones,Ronen Sumagin,Roland Hilgarth,Ashfaqul Alam,Gabrielle Fredman,Ioannis Argyris,Emile Rijcken,Dennis H. M. Kusters,Chris P. M. Reutelingsperger,Mauro Perretti,Charles A. Parkos,Omid C. Farokhzad,Andrew S. Neish,Asma Nusrat +18 more
TL;DR: It is demonstrated that endogenous annexin A1 is released as a component of extracellular vesicles derived from intestinal epithelial cells, and these ANXA1-containing EVs activate wound repair circuits, suggesting that local delivery of proresolving peptides encapsulated within nanoparticles may represent a potential therapeutic strategy for clinical situations characterized by chronic mucosal injury, such as is seen in patients with IBD.
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Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
Giovanna Leoni,Ashfaqul Alam,Philipp-Alexander Neumann,J. David Lambeth,Guangjie Cheng,James McCoy,Roland Hilgarth,Kousik Kundu,Niren Murthy,Dennis H. M. Kusters,Chris P. M. Reutelingsperger,Mauro Perretti,Charles A. Parkos,Andrew S. Neish,Asma Nusrat +14 more
TL;DR: A novel epithelial FPR1/NOX1-dependent redox signaling pathway that promotes mucosal wound repair is delineated and regulated by epithelial cell migration.
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Wound repair: role of immune–epithelial interactions
TL;DR: An improved understanding of mechanisms that mediate repair is important in the development of therapeutics aimed to promote mucosal wound repair.
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The microenvironment of injured murine gut elicits a local pro-restitutive microbiota
Ashfaqul Alam,Giovanna Leoni,Miguel Quiros,Huixia Wu,Chirayu Desai,Hikaru Nishio,Rheinallt M. Jones,Asma Nusrat,Andrew S. Neish +8 more
TL;DR: How wound microenvironments induce the rapid emergence of ‘probiont’ species that contribute to enhanced repair of mucosal wounds is demonstrated and such microorganisms could be exploited as potential therapeutics.
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Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling
Miguel Quiros,Hikaru Nishio,Philipp Neumann,Dorothee Siuda,Jennifer C. Brazil,Veronica Azcutia,Roland Hilgarth,Monique N. O’Leary,Vicky Garcia-Hernandez,Giovanna Leoni,Mingli Feng,Gabriela Bernal,Holly C. Williams,Priya H. Dedhia,Christian Gerner-Smidt,Jason R. Spence,Charles A. Parkos,Timothy L. Denning,Asma Nusrat +18 more
TL;DR: The involvement of macrophages in regulating an IL-10/CREB/WISP-1 signaling axis is defined, with broad implications in linking innate immune activation to mucosal wound repair.