T
Timothy L. Denning
Researcher at Georgia State University
Publications - 82
Citations - 6755
Timothy L. Denning is an academic researcher from Georgia State University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 37, co-authored 78 publications receiving 5757 citations. Previous affiliations of Timothy L. Denning include Yerkes National Primate Research Center & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.
TL;DR: A population of CD11b+F4/80+CD11c− macrophages in the lamina propria that expressed several anti-inflammatory molecules, including interleukin 10 (IL-10), but little or no proinflammatory cytokines, even after stimulation with Toll-like receptor ligands is described.
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Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
Stephanie M. Dillon,Sudhanshu Agrawal,Kaustuv Banerjee,John J. Letterio,Timothy L. Denning,Kyra Oswald-Richter,Deborah J. Kasprowicz,Kathryn L. Kellar,Jeff Pare,Thomas E. Van Dyke,Steven F. Ziegler,Derya Unutmaz,Bali Pulendran +12 more
TL;DR: It is shown that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance and suggest several targets for pharmacological modulation of immune responses in various clinical settings.
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Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
Anna Cebula,Michal Seweryn,Michal Seweryn,Grzegorz A. Rempala,Simarjot Pabla,Richard A. McIndoe,Timothy L. Denning,Lynn Bry,Piotr Kraj,Pawel Kisielow,Leszek Ignatowicz +10 more
TL;DR: Thymus-derived Treg cells constitute most TReg cells in all lymphoid and intestinal organs, including the colon, where their repertoire is heavily influenced by the composition of the microbiota, and their reactivity against specific commensal species is analysed.
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Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization
Timothy L. Denning,Brian A. Norris,Oscar Medina-Contreras,Santhakumar Manicassamy,Duke Geem,Rajat Madan,Christopher L. Karp,Bali Pulendran +7 more
TL;DR: The ability of DC and macrophage subsets to induce Foxp3+ Treg cells versus Th17 cells was strikingly dependent on the source of the mouse strain, and the functional specializations of APC subsets in the intestine were determined.
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Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.
Santhakumar Manicassamy,Rajesh Ravindran,Jiusheng Deng,Herold Oluoch,Timothy L. Denning,Sudhir Pai Kasturi,Kristen M. Rosenthal,Brian D. Evavold,Bali Pulendran,Bali Pulendran +9 more
TL;DR: A new mechanism for the systemic induction of retinoic acid and immune suppression against autoimmunity is defined, defined as Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus.