K
Kousik Kundu
Researcher at Wellcome Trust Sanger Institute
Publications - 73
Citations - 4861
Kousik Kundu is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 22, co-authored 69 publications receiving 3595 citations. Previous affiliations of Kousik Kundu include The Wallace H. Coulter Department of Biomedical Engineering & University of Maryland, College Park.
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Journal ArticleDOI
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle,Heather Elding,Heather Elding,Tao Jiang,Dave Allen,Dace Ruklisa,Dace Ruklisa,Alice L. Mann,Daniel Mead,Heleen J. Bouman,Fernando Riveros-Mckay,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,John J. Lambourne,John J. Lambourne,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kate Downes,Kate Downes,Kousik Kundu,Kousik Kundu,Lorenzo Bomba,Kim Berentsen,John Bradley,John Bradley,Louise C. Daugherty,Louise C. Daugherty,Olivier Delaneau,Kathleen Freson,Stephen F. Garner,Stephen F. Garner,Luigi Grassi,Luigi Grassi,Jose A. Guerrero,Jose A. Guerrero,Matthias Haimel,Eva M. Janssen-Megens,Anita Kaan,Mihir A Kamat,Bowon Kim,Amit Mandoli,Jonathan Marchini,Jonathan Marchini,Joost H.A. Martens,Stuart Meacham,Stuart Meacham,Karyn Megy,Karyn Megy,Jared O'Connell,Jared O'Connell,Romina Petersen,Romina Petersen,Nilofar Sharifi,S.M. Sheard,James R Staley,Salih Tuna,Martijn van der Ent,Klaudia Walter,Shuang-Yin Wang,Eleanor Wheeler,Steven P. Wilder,Valentina Iotchkova,Valentina Iotchkova,Carmel Moore,Jennifer G. Sambrook,Jennifer G. Sambrook,Hendrik G. Stunnenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Stephen Kaptoge,Stephen Kaptoge,Taco W. Kuijpers,Enrique Carrillo-de-Santa-Pau,David Juan,Daniel Rico,Alfonso Valencia,Lu Chen,Lu Chen,Bing Ge,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yang,Roderic Guigó,Stephan Beck,Dirk S. Paul,Dirk S. Paul,Tomi Pastinen,David Bujold,Guillaume Bourque,Mattia Frontini,Mattia Frontini,Mattia Frontini,John Danesh,David J. Roberts,David J. Roberts,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Adam S. Butterworth,Nicole Soranzo +103 more
TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.
Journal ArticleDOI
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Lu Chen,Lu Chen,Bing Ge,Francesco Paolo Casale,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yan,Kousik Kundu,Kousik Kundu,Simone Ecker,Avik Datta,David J. Richardson,Frances Burden,Frances Burden,Daniel Mead,Alice L. Mann,José M. Fernández,Sophia Rowlston,Sophia Rowlston,Steven P. Wilder,Samantha Farrow,Samantha Farrow,Xiaojian Shao,John J. Lambourne,Adriana Redensek,Cornelis A. Albers,Vyacheslav Amstislavskiy,Sofie Ashford,Sofie Ashford,Kim Berentsen,Lorenzo Bomba,Guillaume Bourque,David Bujold,Stephan Busche,Maxime Caron,Shu-Huang Chen,Warren A. Cheung,Oliver Delaneau,Emmanouil T. Dermitzakis,Heather Elding,Irina Colgiu,Frederik Otzen Bagger,Frederik Otzen Bagger,Frederik Otzen Bagger,Paul Flicek,Ehsan Habibi,Valentina Iotchkova,Valentina Iotchkova,Eva M. Janssen-Megens,Bowon Kim,Hans Lehrach,Ernesto Lowy,Amit Mandoli,Filomena Matarese,Matthew T. Maurano,John A. Morris,Vera Pancaldi,Farzin Pourfarzad,Karola Rehnström,Karola Rehnström,Augusto Rendon,Thomas Risch,Nilofar Sharifi,Marie-Michelle Simon,Marc Sultan,Alfonso Valencia,Klaudia Walter,Shuang-Yin Wang,Mattia Frontini,Mattia Frontini,Mattia Frontini,Stylianos E. Antonarakis,Laura Clarke,Marie-Laure Yaspo,Stephan Beck,Roderic Guigó,Daniel Rico,Joost H.A. Martens,Willem H. Ouwehand,Taco W. Kuijpers,Taco W. Kuijpers,Dirk S. Paul,Dirk S. Paul,Hendrik G. Stunnenberg,Oliver Stegle,Kate Downes,Kate Downes,Tomi Pastinen,Nicole Soranzo +90 more
TL;DR: High-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types from up to 197 individuals yields insights into cell-type-specific correlation between diverse genomic inputs, more generalizable correlations between these inputs, and defines molecular events that may underpin complex disease risk.
Journal ArticleDOI
Hydrocyanines: a class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo
Kousik Kundu,Sarah F. Knight,Nick J. Willett,Sungmun Lee,W. Robert Taylor,W. Robert Taylor,W. Robert Taylor,Niren Murthy +7 more
TL;DR: A new family of fluorescent ROS sensors, termed the hydrocyanines, are presented, which can be synthesized in one step from the commercially available cyanine dyes and can detect superoxide and the hydroxyl radical in living cells, tissue samples, and for the first time in vivo.
Journal ArticleDOI
The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling
Hua Tang,Weiping Cao,Sudhir Pai Kasturi,Rajesh Ravindran,Helder I. Nakaya,Kousik Kundu,Niren Murthy,Thomas B. Kepler,Bernard Malissen,Bali Pulendran +9 more
TL;DR: It is demonstrated that cysteine protease–induced TH2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4) via ROS-mediated signaling.
Journal ArticleDOI
The polygenic and monogenic basis of blood traits and diseases
Dragana Vuckovic,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Peter W.F. Wilson,Hélène Choquet,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Qi Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,J. M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotios Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Kelly Cho,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Yukinori Okada,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo +113 more
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.