G
Giovanna Poce
Researcher at Sapienza University of Rome
Publications - 62
Citations - 1777
Giovanna Poce is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Antimycobacterial & Mycobacterium tuberculosis. The author has an hindex of 21, co-authored 57 publications receiving 1421 citations. Previous affiliations of Giovanna Poce include Harvard University & University of Cagliari.
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Journal ArticleDOI
MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
Valentina La Rosa,Giovanna Poce,Julio Ortiz Canseco,Silvia Buroni,Maria Rosalia Pasca,Mariangela Biava,Ravikiran M. Raju,Giulio Cesare Porretta,S. Alfonso,Claudio Battilocchio,Babak Javid,Flavia Sorrentino,Thomas R. Ioerger,James C. Sacchettini,Fabrizio Manetti,Maurizio Botta,Alessandro De Logu,Eric J. Rubin,Edda De Rossi +18 more
TL;DR: The screening of genomic libraries and whole-genome sequencing found that all the characterized mutants showed mutations in the mmpL3 gene, allowing us to conclude that resistance to BM212 maps to the MMPL3 protein, a member of the MmpL (mycobacterial membrane protein, large) family.
Journal ArticleDOI
MmpL3 is the flippase for mycolic acids in mycobacteria
TL;DR: This study established the role of an essential membrane protein as the flippase for MAs and demonstrated that this protein is a direct target of an antimycobacterial compound and provides fundamental insights into OM biogenesis and MA transport in mycobacteria.
Journal ArticleDOI
Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity.
Mariangela Biava,G. C. Porretta,Giovanna Poce,Sibilla Supino,Delia Deidda,Raffaello Pompei,Paola Molicotti,Fabrizio Manetti,Maurizio Botta +8 more
TL;DR: The design and synthesis of new analogues of 1,5-chlorophenyl)-2-methyl-3-(4-methylpiperazin-1-yl)methyl-1H-pyrrole (BM212) are reported, showing that, although some nontuberculosis mycobacterial strains were found to be sensitive, MIC values were higher than those found toward MTB.
Journal ArticleDOI
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.
Giovanna Poce,Robert H. Bates,S. Alfonso,Martina Cocozza,Giulio Cesare Porretta,Lluis Ballell,Joaquín Rullas,Fátima Ortega,Alessandro De Logu,E Agus,Valentina La Rosa,Maria Rosalia Pasca,Edda De Rossi,Baojie Wae,Scott G. Franzblau,Fabrizio Manetti,Maurizio Botta,Mariangela Biava +17 more
TL;DR: In vitro and in vivo target validation evidence presented here adds further weight to MmpL3 as a druggable target of interest for anti-tubercular drug discovery.
Journal ArticleDOI
1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.
M. Biava,G. C. Porretta,Giovanna Poce,Alessandro De Logu,M Saddi,Rita Meleddu,Fabrizio Manetti,Edda De Rossi,Maurizio Botta +8 more
TL;DR: The most active derivatives of new derivatives of 1,5-bis(4-chlorophenyl)-2-methyl-3-(4-methylpiperazin-1-yl)methyl-1H-pyrrole showed activity between 0.125-0.5 microg/mL and protection index higher than 16 and similar to isoniazid and streptomycin.