Giovanni Galli

TL;DR: It is reported that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose‐dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates.

TL;DR: EVOO consumption by mildly dyslipidemic patients is associated with favorable changes in circulating markers of cardiovascular condition, and these effects may be associated with cardioprotection.

TL;DR: Results reveal a novel regulatory mechanism that controls gene transcription in response to extracellular stimuli and argue that the transcription regulation by bile acids of genes central to cholesterol and glucose metabolism should be viewed dynamically in the context of the fasted-to-fed cycle.

TL;DR: The administration of oil samples with increasing amounts of orthodiphenolic compounds, namely hydroxytyrosol and oleuropein aglycone, results in a dose-dependent reduction in the urinary excretion of 8-iso-PGF(2alpha), and a statistically significant negative correlation between homovanillyl alcohol and HValc urinary concentrations suggests that this metabolite better reflects the in vivo activities of hydroxyTYrosol.

TL;DR: HNF-4, in combination with a MAPK signaling pathway, acts as a bile acid sensor in the liver for the first time, suggesting a link between the cascades elicited by bile acids and pro-inflammatory stimuli in the Liver.