G
Giovanni Maga
Researcher at National Research Council
Publications - 273
Citations - 11095
Giovanni Maga is an academic researcher from National Research Council. The author has contributed to research in topics: DNA polymerase & Reverse transcriptase. The author has an hindex of 51, co-authored 263 publications receiving 10032 citations. Previous affiliations of Giovanni Maga include Centre national de la recherche scientifique & Rega Institute for Medical Research.
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Journal ArticleDOI
Proliferating cell nuclear antigen (PCNA): a dancer with many partners.
Giovanni Maga,Ulrich Hübscher +1 more
TL;DR: Structural and biochemical studies are starting to provide a first glimpse of how both PCNA temporally and spatially organise their functions and how both tasks can be achieved.
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Eukaryotic DNA polymerases.
TL;DR: This work has shown that nature has provided various safety mechanisms for the variety of novel pols identified in the last three years, including the lesion-replicating enzymes pol zeta, pol eta, pol iota, pol kappa, and Rev1, and a group of pols called pol theta that fulfill a variety of other tasks.
Journal ArticleDOI
Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol
Lucia Anna Stivala,Monica Savio,Federico Carafoli,Paola Perucca,Livia Bianchi,Giovanni Maga,Luca Forti,Ugo Maria Pagnoni,Angelo Albini,Ennio Prosperi,Vanio Vannini +10 more
TL;DR: The results showed that the hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, and the presence of 4′-OH together with stereoisomery in the trans-conformation was absolutely required for inhibition of cell proliferation.
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A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping.
TL;DR: This review provides an update of the structural and functional data on the key actors of the replicatory machinery of SARS-CoV-2, to fill the gaps in the currently available structural data, which is mainly obtained through homology modeling.
Journal ArticleDOI
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins
Giovanni Maga,Giuseppe Villani,Emmanuele Crespan,Ursula Wimmer,Elena Ferrari,Barbara Bertocci,Ulrich Hübscher +6 more
TL;DR: The findings show the existence of an accurate mechanism to reduce the deleterious consequences of oxidative damage and point to an important role for PCNA and RP-A in determining a functional hierarchy among different DNA pols in lesion bypass.