Vanio Vannini

TL;DR: The results showed that the hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, and the presence of 4′-OH together with stereoisomery in the trans-conformation was absolutely required for inhibition of cell proliferation.

TL;DR: The direct evidence of the formation of free radicals supports the hypothesis that free radicals play a role in the pathogenesis of the histological damage during brain ischemia.

TL;DR: All dietary flavonoid studied show a significant antioxidant effect in a chemical model system, but only epigallocatechin gallate or gallic acid are able to interfere with the cell cycle in Caco2 cell lines, suggesting that the antioxidant activity of flavonoids is not related to the inhibition of cellular growth.

TL;DR: In this paper, 3,5,4′-trimethoxystilbene was shown to be 30 to 100 times more potent than parent compound in inhibiting endothelial cell proliferation, sprouting, collagen gel invasion, and morphogenesis (ID50 = 0.3-3.0 μM).

TL;DR: The formation of PBN-free radical adducts has also been observed in phenobarbital-induced rats in vivo when intoxicated with chloroform, bromoform or iodoform, suggesting that the reductive metabolism of trihalomethanes might be of relevance to their established toxicity in the whole animal.