Gireesh Gangadharan

TL;DR: It is demonstrated that T-type Ca2+ channels in the septo-hippocampal GABAergic pathway play a specific role in control of exploratory behavior of novel objects and that type 2 but not type 1 hippocampal theta rhythm is associated with object exploration.

TL;DR: The results suggest that “tonic GABA inhibition” mediated by extrasynaptic GABAA receptors in MD neurons, suppresses fear extinction learning, raising a possibility that pharmacological control of tonic mode of GabAA receptor activation may be a target for treatment of anxiety disorders like post-traumatic stress disorder.

TL;DR: Evidence is provided that the opioid circuit is bifurcated into two distinct pathways, each with an opposing effect on opioid analgesia at the PAG level: suppressing through the P AG-LC pathway while enhancing through thePAG-rostral ventromedial medulla pathway, suggesting the yin-and-yang model is proposed for the opioidergic descending analgesia.

TL;DR: This paper showed that reciprocal projections between the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing.

TL;DR: In this paper , the authors reviewed the evidence from mouse models that shows how synchronized oscillatory activity is intricately linked to AD machinery, and they primarily focused on recent reports showing abnormal oscillatory activities at theta and gamma frequencies in AD condition and their influence on cellular disturbances and cognitive impairments.