Masahiko Watanabe

TL;DR: Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury, which can be attributed to elevated levels of residual glutamate in the brains of these mice.

TL;DR: This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.

TL;DR: Results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall by generating and analyzing a genetically engineered mouse strain in which the N-methyl-d-asparate (NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice.

TL;DR: Findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development, and the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development.

TL;DR: For example, this paper found that the locus coeruleus is especially sensitive to environmental novelty and locus co-activation of TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.