G
Gisela Borges
Researcher at Instituto de Biologia Molecular e Celular
Publications - 7
Citations - 411
Gisela Borges is an academic researcher from Instituto de Biologia Molecular e Celular. The author has contributed to research in topics: Locus coeruleus & Threshold of pain. The author has an hindex of 6, co-authored 7 publications receiving 323 citations. Previous affiliations of Gisela Borges include University of Cádiz.
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Journal ArticleDOI
Noradrenergic Locus Coeruleus pathways in pain modulation.
Meritxell Llorca-Torralba,Gisela Borges,Fani Neto,Juan Antonio Mico,Esther Berrocoso,Esther Berrocoso +5 more
TL;DR: The main goal of this review is to bring together the data available regarding the noradrenergic system in relation to pain, particularly focusing on the ascending and descending LC projections in different conditions.
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Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence
TL;DR: Preclinical and clinical studies aimed at disclosing the role of neurotrophins in the pathophysiological mechanisms of depression and the mode of action of antidepressants, which favour the neurotrophic/neurogenic hypothesis are reviewed.
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The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain
Cristina Alba-Delgado,Cristina Alba-Delgado,Gisela Borges,Gisela Borges,Pilar Sánchez-Blázquez,Pilar Sánchez-Blázquez,Jorge E. Ortega,Jorge E. Ortega,Igor Horrillo,Igor Horrillo,Juan Antonio Mico,Juan Antonio Mico,J. Javier Meana,J. Javier Meana,Fani Neto,Esther Berrocoso,Esther Berrocoso +16 more
TL;DR: Neuropathic pain is not accompanied by modifications in tonic LC activity after the onset of pain, which may indicate that the signals from the PGi and DRN, the excitatory and inhibitory afferents of the LC, cancel one another out.
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Reversal of monoarthritis-induced affective disorders by diclofenac in rats.
TL;DR: Chronic monoarthritis induces affective disorders associated with ERK1/2 phosphorylation in paragigantocellularis, locus coeruleus, and prefrontal cortex which are reversed by diclofenac analgesia.
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ERK1/2: Function, signaling and implication in pain and pain-related anxio-depressive disorders
TL;DR: The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are molecules strongly implicated in the somatic component of pain at the spinal cord level and have been emerging as mediators of the emotional-affective component as well, and their use as pharmacological targets is still open to discussion.