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Giulio Abagnale
Researcher at RWTH Aachen University
Publications - 8
Citations - 731
Giulio Abagnale is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryoid body. The author has an hindex of 5, co-authored 7 publications receiving 567 citations. Previous affiliations of Giulio Abagnale include Community College of Rhode Island.
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Journal ArticleDOI
Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages
Giulio Abagnale,Michael Steger,Vu Hoa Nguyen,Nils Hersch,Antonio Sechi,Sylvia Joussen,Bernd Denecke,Rudolf Merkel,Bernd Hoffmann,Alice Dreser,Uwe Schnakenberg,Arnold Gillner,Wolfgang Wagner +12 more
TL;DR: This study systematically compared in vitro differentiation of mesenchymal stem cells (MSCs) on a variety of groove/ridge structures to provide further insight into how structuring of tailored biomaterials and implant interfaces do not induce differentiation of MSCs per se, but support their directed differentiation.
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Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells.
Joana Frobel,Hatim Hemeda,Michael Lenz,Giulio Abagnale,Sylvia Joussen,Bernd Denecke,Tomo Saric,Martin Zenke,Wolfgang Wagner +8 more
TL;DR: Overall, iPS-MSCs are similar to MSCs, but they reveal incomplete reacquisition of immunomodulatory function and MSC-specific DNAm patterns—particularly ofDNAm patterns associated with tissue type and aging.
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Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies
Giulio Abagnale,Antonio Sechi,Michael Steger,Qihui Zhou,Chao-Chung Kuo,Gülcan Aydin,Carmen Schalla,Gerhard Müller-Newen,Martin Zenke,Ivan G. Costa,Patrick van Rijn,Arnold Gillner,Wolfgang Wagner +12 more
TL;DR: It is demonstrated that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, and direct the polarity of cell division.
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Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells
Eduardo Fernandez-Rebollo,Birgit Mentrup,Regina Ebert,Julia Franzen,Giulio Abagnale,Torsten Sieben,Alina Ostrowska,Per Hoffmann,Per Hoffmann,Pierre-François Roux,Björn Rath,Michele Goodhardt,Jean-Marc Lemaitre,Oliver Bischof,Franz Jakob,Wolfgang Wagner +15 more
TL;DR: This work isolated and expanded human bone marrow-derived MSCs in parallel with HPL and demonstrated that HPL significantly increases proliferation and leads to dramatic differences in cellular morphology, while global DNA-methylation profiles did not reveal any significant differences.
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3D non-woven polyvinylidene fluoride scaffolds: fibre cross section and texturizing patterns have impact on growth of mesenchymal stromal cells.
Anne Schellenberg,Robin Ross,Giulio Abagnale,Sylvia Joussen,Philipp Schuster,Annahit Arshi,Norbert Pallua,Stefan Jockenhoevel,Thomas Gries,Wolfgang Wagner +9 more
TL;DR: 3D PVDF non-woven scaffolds support growth of MSCs, however fibre morphology and mesh size are relevant: proliferation is enhanced by round fibre cross sections and in rather wide-meshed scaffolds.