Joana Frobel

TL;DR: Overall, iPS-MSCs are similar to MSCs, but they reveal incomplete reacquisition of immunomodulatory function and MSC-specific DNAm patterns—particularly ofDNAm patterns associated with tissue type and aging.

TL;DR: An alternative concept to use DNAm patterns for molecular definition of cell preparations, and the epigenetic scores facilitate robust and cost-effective quality control of MSC cultures are proposed.

TL;DR: White blood cell counts can be reliably determined by site-specific DNAm analysis and is applicable to very small blood volumes and frozen samples, and it allows for more standardized and cost-effective analysis in clinical application.

TL;DR: Analysis of DNAm at C1R provides a simple, robust, and cost-effective biomarker to further complement risk assessment in AML, and indicates that DNAm of C1 R is a biomarker reflecting chromatin reorganization rather than being of pathophysiological relevance per se.

TL;DR: Epigenetic changes of human hematopoietic development are recapitulated in the murine transplantation model, whereas epigenetic aging is not accelerated by the faster aging environment and seems to occur in the cell intrinsically.