Sylvia Joussen

TL;DR: This study systematically compared in vitro differentiation of mesenchymal stem cells (MSCs) on a variety of groove/ridge structures to provide further insight into how structuring of tailored biomaterials and implant interfaces do not induce differentiation of MSCs per se, but support their directed differentiation.

TL;DR: Overall, iPS-MSCs are similar to MSCs, but they reveal incomplete reacquisition of immunomodulatory function and MSC-specific DNAm patterns—particularly ofDNAm patterns associated with tissue type and aging.

TL;DR: Culture expansion of MSC has profound functional implications - these are hardly reflected by genomic instability but they are associated with highly reproducible DNA-methylation changes which correlate with repressive histone marks, therefore replicative senescence seems to be epigenetically controlled.

TL;DR: It is demonstrated that gene expression changes and epigenetic modifications are continuously acquired during replicative senescence in Mesenchymal stromal cells.

TL;DR: It is demonstrated that HOTAIR impacts on differentiation of MSCs and that it is associated with senescence-associated DNAm, and targeting of epigenetic modifiers to relevant loci in the genome may involve triple helix formation with HotaIR.