Giustina Simone

TL;DR: A pulse radiolysis study of glutathione in aqueous solution at pH 5.5 containing N2O/O2 mixtures at various ratios indicates that oxygen rapidly adds to the thiyl glutathion radical yielding a transient absorption, with a maximum at 540 nm, whose characteristics appear to be compatible with assignment to the GSOO.

TL;DR: The hypothesis that complex, less reparable DSB are induced in higher proportion by light ions with respect to gamma-rays and that, for the same ion, increasing LET leads to an increase in this proportion is supported.

TL;DR: The combination of experimental, theoretical and simulation data supports the hypothesis of an interdependent processing of closely associated DSBs, possibly associated with a diminished correct repair capability, which affects cell killing and lethal mutation.

TL;DR: The main outcome was that small fragments (<23 kbp) are produced almost exclusively via non-random processes, since their number is considerably higher than that produced by a random insertion of DSB.

TL;DR: In this paper, the authors describe the proton irradiation facility built up at the 7 MV Van de Graaff accelerator of the INFN-Laboratori Nazionali di Legnaro for radiobiological studies, which consists of two vacuum chambers, a fast tantalum shutter for intercepting the beam and a beam line containing the beam collimator arrangement and ending with a thin window for the beam extraction in air.