G
Gloria Alzuet
Researcher at University of Valencia
Publications - 63
Citations - 2479
Gloria Alzuet is an academic researcher from University of Valencia. The author has contributed to research in topics: Crystal structure & Copper. The author has an hindex of 31, co-authored 63 publications receiving 2358 citations. Previous affiliations of Gloria Alzuet include University of Santiago de Compostela.
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Journal ArticleDOI
Toward the development of metal-based synthetic nucleases: DNA binding and oxidative DNA cleavage of a mixed copper(II) complex with N-(9H-purin-6-yl)benzenesulfonamide and 1,10-phenantroline. Antitumor activity in human Caco-2 cells and Jurkat T lymphocytes. Evaluation of p53 and Bcl-2 proteins in the apoptotic mechanism.
José Luis García-Giménez,Marta González-Álvarez,Malva Liu-González,Benigno Macías,Joaquín Borrás,Gloria Alzuet +5 more
TL;DR: The complex was found to be a very efficient agent of plasmid DNA cleavage in the presence of ascorbate and demonstrated a significant ability to induce cell death by apoptosis.
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Antibacterial studies, DNA oxidative cleavage, and crystal structures of Cu(II) and Co(II) complexes with two quinolone family members, ciprofloxacin and enoxacin.
N. Jiménez-Garrido,L. Perelló,R. Ortiz,Gloria Alzuet,Marta González-Álvarez,E Cantón,Malva Liu-González,Santiago García-Granda,Mónica Pérez-Priede +8 more
TL;DR: Mechanistic studies using different inhibiting reagents reveal that hydroxyl radicals are involved in the DNA scission process mediated by this compound, and the results show that the complex behaves as an efficient chemical nuclease with ascorbate/hydrogen peroxide activation.
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Oxidative Cleavage of DNA by a New Ferromagnetic Linear Trinuclear Copper(II) Complex in the Presence of H2O2/Sodium Ascorbate
TL;DR: The trinuclear complex cleaves DNA efficiently, in the presence of hydrogen peroxide/sodium ascorbate, and tert-Butyl alcohol and sodium azide inhibit the oxidative cleavage, suggesting that the hydroxyl radical and singlet oxygen are involved in the DNA degradation.
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Countercomplementarity and strong ferromagnetic coupling in a linear mixed mu-acetato, mu-hydroxo trinuclear copper(II) complex. Synthesis, structure, magnetic properties, EPR, and theoretical studies.
Laura Gutierrez,Gloria Alzuet,José Antonio Real,Joan Cano,Joaquín Borrás,Alfonso Castiñeiras +5 more
TL;DR: The ferromagnetic exchange coupling is discussed using DFT calculations on model compounds that have shown a countercomplementary effect of the hydroxo and acetate bridges.
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DNA cleavage studies of mononuclear and dinuclear copper(II) complexes with benzothiazolesulfonamide ligands.
TL;DR: Copper-based transition metal complexes performing single- and double-strand scission of DNA have been studied, suggesting that the dinuclearity is an important factor in the oxidative cleavage of DNA.