Showing papers in "Journal of Inorganic Biochemistry in 2005"

TL;DR: The results showed that the bactericidal efficacy of nano-MgO increases with decreasing particle size, and nano- MgO is active even in the absence of irradiation.

TL;DR: The defining characteristics of heme-based sensors are elaborated, recent developments on those proteins are examined, and regulatory hypotheses proposed for those sensors are discussed.

TL;DR: Crystal structures have revealed the structural basis of isoform-selective inhibition by a group of dipeptide inhibitors which opens the way for structure-based inhibitor design.

TL;DR: Present evidence points to an important role of neuroglobin in neuronal oxygen homeostasis and hypoxia protection, though other functions are still conceivable, as first glimpse into the possible physiological roles of these globins in the animal's metabolism.

TL;DR: High affinity flavoHb and Hb heme ligands, and other inhibitors, may find application as antibiotics and antitumor agents that enhance the toxicity of immune cell-derived *NO or as vasorelaxants that increase *NO signalling.

TL;DR: There is currently a broadening of the scope of NO functionality and an increase in awareness that other heme-based NO-metabolizing systems contribute to the overall capability of the prokaryotic cell to cope with NO both in anaerobic and aerobic environments, including the pathogen-host interface.

TL;DR: Observed changes in the viscosity and circular dichroic spectrum of calf thymus DNA solution in the presence ofcomplex 1 suggests intercalative binding of complex 1 to DNA.

TL;DR: Results reported here demonstrate that aluminium in the form of aluminium chloride or aluminium chlorhydrate can interfere with the function of oestrogen receptors of MCF7 human breast cancer cells both in terms of ligand binding and in terms Ofstedrogen-regulated reporter gene expression, adding aluminium to the increasing list of metals capable of interfering with oestrogens action and termed metalloestrogens.

TL;DR: Carbon monoxide is a useful vibrational probe of heme binding sites in proteins, because FeCO backbonding is modulated by polar interactions with protein residues, and by variations in the donor strength of the trans ligand.

TL;DR: Interestingly, [Cu(L5)]2+ shows the highest DNA cleavage activity among all the present copper(II) complexes suggesting that the bulky N-tert-butyl group plays an important role in modifying the coordination environment around the copper( II) center, the Cu(II)/Cu(I) redox potential and hence the formation of activated oxidant responsible for the cleavage.

TL;DR: In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazones analogue.

TL;DR: The initial part of the description of the InsP6-multivalent cation chemistry is reported, including its solution equilibria studied by high resolution potentiometry and (for the Fe(III)/Fe(II) couple) cyclic voltammetry.

TL;DR: The reaction between nitrite and hemoglobin has been studied for over a century, but recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction.

TL;DR: All complexes show a quite similar planar fourfold environment around palladium(II).

TL;DR: In this paper, the kissing bug ( Rhodnius prolixus) and the bedbug ( Cimex lectularius) were found to have a large component of β-sheet structure, which is unusual for heme proteins.

TL;DR: The physico-chemical studies of benzoates, salicylates, 3-pyridine carboxylicates and isoorotates are carried out in order to understand the nature of the interactions of these compounds with their biological targets (e.g., receptors in the cell or important cell components).

TL;DR: Mechanistic studies using different inhibiting reagents reveal that hydroxyl radicals are involved in the DNA scission process mediated by this compound, and the results show that the complex behaves as an efficient chemical nuclease with ascorbate/hydrogen peroxide activation.

TL;DR: Vanadyl complexes were, however, more cytotoxic than were the ligands alone in standard MTT cytotoxicity testing, using mouse lymphoma cells, corroborating the importance of curcumin's free phenolic OH groups for scavenging oxidants, and correlated with reduced cytot toxic potential.

TL;DR: Pyrrole derivative [Cu(HL(2))(2)] proved to be a wide spectrum agent, showing an interesting inhibition of the growth of all Gram-positive bacteria and fungi tested at concentrations of 12-50 microg/mL.

TL;DR: The proposed mechanisms of this interaction include the increase of biliary excretion and direct interaction/precipitation of selenium and arsenic, and their effects on zinc finger protein function, cellular signaling and methylation pathways, and how anti-carcinogenic effects of seenium may be affected by arsenic.

TL;DR: The effect of aluminum on AChE activity may be due to a direct neurotoxic effect of the metal or perhaps a disarrangement of the plasmatic membrane caused by increased lipid peroxidation.

TL;DR: Recent progress in investigations of new classes of antifungal compounds: disubstituted aliphatic and aromatic thioureas, triazole and thiazine compounds which act as ligands for transition metals are provided.

TL;DR: Total messenger RNA levels in untransformed human neural cells exposed to 100 nanomolar aluminum sulfate are examined using high density DNA microarrays that interrogate the expression of every human gene, suggesting a role for aluminum, HIF-1 and NF-kappaB in driving atypical, pro-inflammatory and pro-apoptotic gene expression.

TL;DR: The coordination chemistry of the one-electron reduced form of nitric oxide, termed a nitroxyl or nitrosyl hydride (NO- or HNO), is described with special focus on its interaction with hemes and heme model complexes.

TL;DR: A covalent mode of DNA binding of the copper(II) complexes, which involves coordination of most possibly guanine N7 nitrogen of DNA to form a CuN4 chromophore only in the case of the more basic N-meim and GMP is supported.

TL;DR: Complex 1 showed significant cytotoxic activity against three cancer cell lines and the experimental results indicated that complexes 1 and 2 bound to DNA by intercalative mode via the ligand L.

TL;DR: An overview of the reactions of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, with ligands and electrons is presented, pointing out where necessary unresolved facts or questionable interpretations are pointed out.

TL;DR: The results indicate that the two complexes all bind to calf thymus DNA (CT-DNA) in an intercalative mode, and the DNA-binding affinity of complex 2 is greater than that of complex 1, and complex 2 can promote cleavage of pBR322 DNA both upon irradiation and in the dark, with more efficient cleavage occurringUpon irradiation.

TL;DR: Structural bases for heme binding and diatomic ligand recognition by trHbs are reviewed.

TL;DR: The combined potentiometric and spectroscopic studies of interactions of N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid with Cu(II) demonstrated that this popular buffer forms a CuL+ complex, with the logbeta(CuL) value of 3.22.