G
Gordon M. Cragg
Researcher at National Institutes of Health
Publications - 109
Citations - 35531
Gordon M. Cragg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Drug discovery & Camptothecin. The author has an hindex of 48, co-authored 109 publications receiving 30936 citations.
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Journal ArticleDOI
Antitumor Agents. 228. Five New Agarofurans, Reissantins A−E, and Cytotoxic Principles from Reissantia buchananii
Fang Rong Chang,Ken-ichiro Hayashi,IS Chen,Chih Chuang Liaw,Kenneth F. Bastow,Yuka Nakanishi,Hiroshi Nozaki,Gordon M. Cragg,Yang-Chang Wu,Kuo-Hsiung Lee +9 more
TL;DR: Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agar ofuran pyridine alkaloids.
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Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea
George R. Pettit,Atsushi Numata,Chika Iwamoto,Yoshihide Usami,Takeshi Yamada,Hirofumi Ohishi,Gordon M. Cragg +6 more
TL;DR: Bioassay-guided separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea led to the isolation of four new dibenz[b,f]oxepins named bauhiniastatins 1−4, as well as the known and related pacharin as cancer cell growth inhibitors.
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Plants as a source of anti-cancer and anti-HIV agents
Gordon M. Cragg,David J. Newman +1 more
TL;DR: Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents, including vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecans, etoposide, and paclitaxel.
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Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization
TL;DR: This is the first known example of a flavone with antimitotic activity and inhibited tubulin polymerization, inhibited the binding of [3H]-colchicine to tubulin, and induced mitotic figure formation in whole cells at cytotoxic concentrations.
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Endophytic and epiphytic microbes as "sources" of bioactive agents.
David J. Newman,Gordon M. Cragg +1 more
TL;DR: Examples from insects, plants, and marine invertebrates are given to give examples of how interactions within the macroorganism, or in certain cases, a fungus, ends up with the production of a novel agent that has potential as a treatment for a human disease.