G
Gorica Nikoloski
Researcher at Radboud University Nijmegen Medical Centre
Publications - 10
Citations - 978
Gorica Nikoloski is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Retinoic acid receptor alpha & Transactivation. The author has an hindex of 7, co-authored 10 publications receiving 918 citations. Previous affiliations of Gorica Nikoloski include Erasmus University Medical Center & Radboud University Nijmegen.
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Journal ArticleDOI
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Gorica Nikoloski,Saskia Langemeijer,Roland P. Kuiper,Ruth Knops,Marion Massop,Evelyn Tönnissen,Adrian van der Heijden,Theresia N Scheele,Peter Vandenberghe,Theo de Witte,Bert A. van der Reijden,Joop H. Jansen +11 more
TL;DR: Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZh2 is a tumor suppressor in myelodysplastic syndromes.
Journal ArticleDOI
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
Jonas S. Jutzi,Ruzhica Bogeska,Gorica Nikoloski,Corina A. Schmid,Thalia S. Seeger,Frank Stegelmann,Sven Schwemmers,Albert Gründer,Jan C. Peeken,Monika Gothwal,Julius Wehrle,Konrad Aumann,Kamar Hamdi,Christine Dierks,Wei Kamar Wang,Konstanze Döhner,Joop H. Jansen,Heike L. Pahl +17 more
TL;DR: Mutations in the transcription factor NF-E2 in patients with myeloproliferative neoplasms result in a truncated protein that enhances the function of wild-type NF- E2 and causes erythrocytosis and throbocytosis in a mouse model.
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The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.
Jurgen A. Marteijn,Jurgen A. Marteijn,Liesbeth van Emst,Liesbeth van Emst,Claudia A.J. Erpelinck-Verschueren,Claudia A.J. Erpelinck-Verschueren,Gorica Nikoloski,Gorica Nikoloski,Aswin L. Menke,Aswin L. Menke,Theo de Witte,Theo de Witte,Bob Löwenberg,Bob Löwenberg,Joop H. Jansen,Joop H. Jansen,Bert A. van der Reijden,Bert A. van der Reijden +17 more
TL;DR: It is concluded that proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells.
Journal ArticleDOI
ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells.
Jeannet Nigten,M.C. Breems-de Ridder,Claudia A.J. Erpelinck-Verschueren,Gorica Nikoloski,B.A. van der Reijden,S. van Wageningen,P. B. Van Hennik,T. de Witte,Bob Löwenberg,Joop H. Jansen +9 more
TL;DR: The identification of two ATRA responsive genes in APL cells, ID1 and ID2, are reported, and the inhibition of specific bHLH transcription factor complexes may play a role in the therapeutic effect of ATRA inAPL.
Journal ArticleDOI
Mutations in epigenetic regulators in myelodysplastic syndromes.
TL;DR: Until recently, the genetic aberrations that are causally linked to the pathogenesis of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms were largely unknown, but using novel technologies, various genes have now been identified that are recurrently mutated.