Goro Watanabe

TL;DR: The feasibility of genomewide expression profiling of formalin-fixed, paraffin-embedded tissues is demonstrated and it is shown that a reproducible gene-expression signature correlated with survival is present in liver tissue adjacent to the tumor in patients with hepatocellular carcinoma.

TL;DR: Three robust HCC subclasses are observed, each correlated with clinical parameters such as tumor size, extent of cellular differentiation, and serum alpha-fetoprotein levels, and it is indicated that S1 reflected aberrant activation of the WNT signaling pathway, S2 was characterized by proliferation as well as MYC and AKT activation, and S3 was associated with hepatocyte differentiation.

TL;DR: In patients with hepatoviral infection, although a wide resection margin can eradicate the microsatellite lesions around hepatocellular carcinoma, a large‐volume hepatectomy may diminish remaining liver function and become an obstacle for treating recurrent HCC.

TL;DR: Cost-effectiveness of RFA in the treatment of small HCC was superior to that of surgery, and local recurrence rates after RFA and surgery were similar.

TL;DR: This is the first report associating heterotopic pancreas in the gallbladder and elevated pancreatic enzymes in bile to play an important role in the occurrence of acalculous cholecystitis and biliary cancer.