K
Kenji Ikeda
Researcher at University of California, San Francisco
Publications - 572
Citations - 23487
Kenji Ikeda is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Hepatocellular carcinoma & Hepatitis C virus. The author has an hindex of 62, co-authored 556 publications receiving 20044 citations. Previous affiliations of Kenji Ikeda include Tokyo Medical and Dental University & Osaka Ohtani University.
Papers
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Journal ArticleDOI
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
Masatoshi Kudo,Richard S. Finn,Shukui Qin,Kwang Hyub Han,Kenji Ikeda,Fabio Piscaglia,Ari David Baron,Joong-Won Park,Guohong Han,Jacek Jassem,Jean-Frédéric Blanc,Arndt Vogel,Dmitry Komov,T.R. Jeffry Evans,Carlos Lopez,Corina E. Dutcus,Matthew Guo,Kenichi Saito,Silvija Kraljevic,Toshiyuki Tamai,Min Ren,Ann-Lii Cheng +21 more
TL;DR: Lenvatinib was non-inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma and the safety and tolerability profiles of lenvatinIB were consistent with those previously observed.
Journal ArticleDOI
Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma
Yujin Hoshida,Augusto Villanueva,Masahiro Kobayashi,Judit Peix,Derek Y. Chiang,Amy L. Camargo,Supriya Gupta,Jamie Moore,Matthew J. Wrobel,Jim Lerner,Michael R. Reich,Jennifer A. Chan,Jonathan N. Glickman,Kenji Ikeda,Masaji Hashimoto,Goro Watanabe,Maria Grazia Daidone,Sasan Roayaie,Myron Schwartz,Swan N. Thung,Helga B. Salvesen,Stacey Gabriel,Vincenzo Mazzaferro,Jordi Bruix,Scott L. Friedman,Hiromitsu Kumada,Josep M. Llovet,Todd R. Golub +27 more
TL;DR: The feasibility of genomewide expression profiling of formalin-fixed, paraffin-embedded tissues is demonstrated and it is shown that a reproducible gene-expression signature correlated with survival is present in liver tissue adjacent to the tumor in patients with hepatocellular carcinoma.
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Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.
Yujin Hoshida,Sebastian M.B. Nijman,Sebastian M.B. Nijman,Masahiro Kobayashi,Jennifer A. Chan,Jennifer A. Chan,Jean Philippe Brunet,Derek Y. Chiang,Augusto Villanueva,Philippa Newell,Kenji Ikeda,Masaji Hashimoto,Goro Watanabe,Stacey Gabriel,Scott L. Friedman,Hiromitsu Kumada,Josep M. Llovet,Todd R. Golub,Todd R. Golub +18 more
TL;DR: Three robust HCC subclasses are observed, each correlated with clinical parameters such as tumor size, extent of cellular differentiation, and serum alpha-fetoprotein levels, and it is indicated that S1 reflected aberrant activation of the WNT signaling pathway, S2 was characterized by proliferation as well as MYC and AKT activation, and S3 was associated with hepatocyte differentiation.
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Long‐term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection
Tetsuya Hosaka,Fumitaka Suzuki,Masahiro Kobayashi,Yuya Seko,Yusuke Kawamura,Hitomi Sezaki,Norio Akuta,Yoshiyuki Suzuki,Satoshi Saitoh,Yasuji Arase,Kenji Ikeda,Mariko Kobayashi,Hiromitsu Kumada +12 more
TL;DR: Long‐term ETV treatment may reduce the incidence of HCC in HBV‐infected patients, and the treatment effect was greater in patients at higher risk of H CC.
Journal ArticleDOI
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.
Hiromitsu Kumada,Yoshiyuki Suzuki,Kenji Ikeda,Joji Toyota,Yoshiyasu Karino,Kazuaki Chayama,Yoshiiku Kawakami,Akio Ido,Kazuhide Yamamoto,Koichi Takaguchi,Namiki Izumi,Kazuhiko Koike,Tetsuo Takehara,Norifumi Kawada,Michio Sata,Hidetaka Miyagoshi,Timothy Eley,Fiona McPhee,Andrew Damokosh,Hiroki Ishikawa,Eric Hughes +20 more
TL;DR: Interferon‐free, ribavirin‐free all‐oral therapy with daclatasvir and asunaprevir for 24 weeks is well tolerated and can achieve a high rate of SVR in patients with HCV genotype 1b who were ineligible, intolerant, or had not responded to prior interferon-based therapy.