J
Judit Peix
Researcher at University of Barcelona
Publications - 24
Citations - 4332
Judit Peix is an academic researcher from University of Barcelona. The author has contributed to research in topics: Hepatocellular carcinoma & HCCS. The author has an hindex of 12, co-authored 18 publications receiving 3590 citations. Previous affiliations of Judit Peix include Mount Sinai Hospital & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma
Yujin Hoshida,Augusto Villanueva,Masahiro Kobayashi,Judit Peix,Derek Y. Chiang,Amy L. Camargo,Supriya Gupta,Jamie Moore,Matthew J. Wrobel,Jim Lerner,Michael R. Reich,Jennifer A. Chan,Jonathan N. Glickman,Kenji Ikeda,Masaji Hashimoto,Goro Watanabe,Maria Grazia Daidone,Sasan Roayaie,Myron Schwartz,Swan N. Thung,Helga B. Salvesen,Stacey Gabriel,Vincenzo Mazzaferro,Jordi Bruix,Scott L. Friedman,Hiromitsu Kumada,Josep M. Llovet,Todd R. Golub +27 more
TL;DR: The feasibility of genomewide expression profiling of formalin-fixed, paraffin-embedded tissues is demonstrated and it is shown that a reproducible gene-expression signature correlated with survival is present in liver tissue adjacent to the tumor in patients with hepatocellular carcinoma.
Journal ArticleDOI
Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma
Augusto Villanueva,Derek Y. Chiang,Pippa Newell,Judit Peix,Swan N. Thung,Clara Alsinet,Victoria Tovar,Sasan Roayaie,Beatriz Minguez,Manel Solé,Carlo Battiston,Stijn van Laarhoven,Maria Isabel Fiel,Analisa Di Feo,Yujin Hoshida,Steven Yea,Sara Toffanin,Alex H. Ramos,John A. Martignetti,Vincenzo Mazzaferro,Jordi Bruix,Samuel Waxman,Myron Schwartz,Matthew Meyerson,Scott L. Friedman,Josep M. Llovet,Josep M. Llovet +26 more
TL;DR: MTOR signaling has a critical role in the pathogenesis of HCC, with evidence for the role of RICTOR in hepato-oncogenesis, and a rationale for targeting the mTOR pathway in clinical trials in HCC is established.
Journal ArticleDOI
Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma
Derek Y. Chiang,Augusto Villanueva,Yujin Hoshida,Yujin Hoshida,Judit Peix,Philippa Newell,Beatriz Minguez,Amanda LeBlanc,Diana J. Donovan,Swan N. Thung,Manel Solé,Victoria Tovar,Clara Alsinet,Alex H. Ramos,Jordi Barretina,Sasan Roayaie,Myron Schwartz,Samuel Waxman,Jordi Bruix,Vincenzo Mazzaferro,Azra H. Ligon,Vesna Najfeld,Scott L. Friedman,William R. Sellers,Matthew Meyerson,Josep M. Llovet +25 more
TL;DR: Overexpression of VEGFA via 6p21 gain in hepatocellular carcinomas suggested a novel, non-cell-autonomous mechanism of oncogene activation, and the prevalence of V EGFA high-level gains in multiple tumor types suggests indications for clinical trials of antiangiogenic therapies.
Journal ArticleDOI
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.
Daniela Sia,Yujin Hoshida,Augusto Villanueva,Sasan Roayaie,Joana Ferrer,Barbara Tabak,Judit Peix,Manel Solé,Victoria Tovar,Clara Alsinet,Helena Cornella,Brandy Klotzle,Jian-Bing Fan,Christian Cotsoglou,Swan N. Thung,Josep Fuster,Samuel Waxman,Juan Carlos García-Valdecasas,Jordi Bruix,Myron Schwartz,Rameen Beroukhim,Rameen Beroukhim,Vincenzo Mazzaferro,Josep M. Llovet +23 more
TL;DR: An integrative genomic analysis of ICC samples from a large series of patients identified a gene expression signature that was associated with reduced survival times of patients with ICC and was enriched in the proliferation class.
BASIC AND TRANSLATIONAL—BILIARY Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes
Daniela Sia,Yujin Hoshida,Augusto Villanueva,Sasan Roayaie,Joana Ferrer,Barbara Tabak,Judit Peix,Manel Solé,Victoria Tovar,Clara Alsinet,Helena Cornella,Brandy Klotzle,Christian Cotsoglou,Swan Thung,Josep Fuster,Samuel Waxman,Jordi Bruix,Myron Schwartz,Rameen Beroukhim,Vincenzo Mazzaferro,Josep M. Llovet +20 more
TL;DR: In this paper, the authors performed an integrative genomic analysis of cholangiocarcinoma (ICC) samples from a large series of patients and identified two main biological classes of ICC: the inflammation class (38% of ICCs) is characterized by activation of inflammatory signaling pathways, overexpression of cytokines, and STAT3 activation.