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Grace Y. Liu
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 1905
Grace Y. Liu is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Methionine & mTORC1. The author has an hindex of 7, co-authored 7 publications receiving 1029 citations. Previous affiliations of Grace Y. Liu include University of Michigan & Anschutz Medical Campus.
Papers
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Journal ArticleDOI
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu,David M. Sabatini +1 more
TL;DR: This Review highlights recent advances in the understanding of the complex regulation of the mTOR pathway and discusses its function in the context of physiology, human disease and pharmacological intervention.
Journal ArticleDOI
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Xin Gu,Jose M. Orozco,Robert A. Saxton,Kendall J. Condon,Grace Y. Liu,Patrycja A. Krawczyk,Sonia M. Scaria,J. Wade Harper,Steven P. Gygi,David M. Sabatini +9 more
TL;DR: In this article, the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 μM.
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Xin Gu,Jose M. Orozco,Robert A. Saxton,Kendall J. Condon,Grace Y. Liu,Patrycja A. Krawczyk,Sonia M. Scaria,J. Wade Harper,Steven P. Gygi,David M. Sabatini +9 more
TL;DR: A potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms is described and a protein named SAMTOR is identified as a component of the nutrient-sensing pathway upstream of m TORC1.
Journal ArticleDOI
Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor
Sarah V. Bradley,Eric C. Holland,Grace Y. Liu,Dafydd G. Thomas,Teresa S. Hyun,Theodora S. Ross +5 more
TL;DR: The findings suggest that HIP1 may up-regulate or maintain EGFR overexpression in primary brain tumors by directly interacting with the receptor and this novel HIP1-EGFR interaction may work with or independent of HIP1 modulation of EGFR degradation via clathrin-mediated membrane trafficking pathways.
Journal ArticleDOI
Huntingtin-Interacting Protein 1: A Merkel Cell Carcinoma Marker that Interacts with c-Kit
Heather M. Ames,Christopher K. Bichakjian,Grace Y. Liu,Katherine Oravecz-Wilson,Douglas R. Fullen,Monique Verhaegen,Timothy M. Johnson,Andrzej A. Dlugosz,Theodora S. Ross +8 more
TL;DR: It is found that the endocytic oncoprotein Huntingtin interacting protein 1 (HIP1) is expressed at high levels in close to 90% of MCC tumors and serves as a more reliable histological cytoplasmic stain than the gold standard, cytokeratin 20 (CK20).