Showing papers in "Journal of Investigative Dermatology in 2011"

TL;DR: Prevalence ranged from 8.7 to 18.1% between states and districts, with the highest prevalence reported in many of the East Coast states, as well as in Nevada, Utah, and Idaho.

TL;DR: The data predict that Psoriasis therapy with either TNF or IL-17 antagonists will produce greater modulation of the synergistic/additive gene set, which consists of the most highly expressed genes in psoriasis skin lesions.

TL;DR: It is shown that the composition of cutaneous microbial communities evolves over the first year of life, showing increasing diversity with age, and that Firmicutes predominate on infant skin.

TL;DR: The results indicate that the IL-36 cytokines are not only regulated by Th 17 cytokines, but that they themselves can regulate the expression and enhance the function of Th17 cytokines.

TL;DR: It is shown that Tregs of patients with severe psoriasis, as compared with those of healthy controls, have an enhanced propensity to differentiate into IL-17A-producing cells on ex vivo stimulation, linked to unexpectedly high RORγt levels and enhanced loss of Foxp3.

TL;DR: Acne is frequently found in late adolescence and is associated with social and psychological problems and adverse events including suicidal ideation and depression that have been associated with therapies for acne may reflect the burden of substantial acne rather than the effects of medication.

TL;DR: Observations indicate that the normal human skin microflora protects skin via various modes of action, a conclusion supported by many lines of evidence associating diseases such as acne, atopic dermatitis, psoriasis and rosacea with an imbalance of the microFLora even in the absence of classical infection.

TL;DR: Observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea.

TL;DR: Risk factors for BP include neurological disorders, particularly dementia and Parkinson's disease, psychiatric disorders (unipolar and bipolar disorders), bedridden condition, and chronic use of several drugs.

TL;DR: Interestingly, commensal bacteria are able to amplify the innate immune response of human keratinocytes to pathogens by increased induction of AMP expression and abrogation of NF-κB suppression, suggesting that the two activation pathways can act in a synergistic way.

TL;DR: Localized melanomas in women had a lower propensity to metastasize, resulting in a better survival when compared with men, even after first disease progression, and this results suggest differences in tumor-host interaction across gender.

TL;DR: It is concluded that targeting Stat3 may lead to a therapy for psoriasis after psoriatic lesions in six of the eight patients showed improvement after topical STA-21 treatment for 2 weeks.

TL;DR: An improved understanding of these interactions will facilitate the development of novel biophysical materials and mechanomodulatory approaches to augment wound repair and regeneration.

TL;DR: A role for miR-125b in the regulation of keratinocyte proliferation and differentiation is demonstrated, partially through theregulation of FGFR2.

TL;DR: In this paper, a matched case-control analysis was conducted to assess the risk of bullous pemphigoid (BP) in patients with neurological diseases. But, the association was only observed where neurological disease was diagnosed before the onset of pemophigoid.

TL;DR: A synopsis of critical findings that have led to the current understanding of the biochemical pathways and melanogenic factors involved in melanin synthesis are presented.

TL;DR: In this article, the authors investigated whether IL-25 may have a role in atopic dermatitis (AD) and found that IL25-producing cells within the dermis of AD patients are dendritic cells (DCs).

TL;DR: It is demonstrated that neutrophil scouts also transit through the non-inflamed dermis, suggesting immunosurveillance function by these cells, and unravels a three-step cascade of events that mediates the specific accumulation of neutrophils at sites of sterile tissue injury in the interstitial space.

TL;DR: It is shown that the defective FLG degradation in caspase-14-deficient skin results in substantial reduction in the amount of NMFs, such as urocanic acid and pyrrolidone carboxylic acid.

TL;DR: It is reported that clinical treatment of psoriasis patients with a TNF-α antagonist results in significant enhancement of epidermal barrier protein expression.

TL;DR: It appears that even when the epidermal reaction in psoriasis is fully resolved, inflammation, as defined by expression of key cytokines and chemokines, is not completely resolved in treated lesions.

TL;DR: It is suggested that TNF-α-activated ASCs accelerate cutaneous wound healing through paracrine mechanisms involving IL-6 and IL-8.

TL;DR: The potential of RDEB iPS cells to generate autologous hematopoietic grafts and skin cells with the inherent capacity to treat skin and mucosal erosions that typify this genodermatosis is identified.

TL;DR: The results suggest that glycemia, as assessed by HbA1c, may be an important biomarker in predicting wound healing rate in diabetic patients.

TL;DR: Although MCV-positive andMCV-negative MCCs may have different etiologies, these tumors have comparable clinical behaviors and prognosis.

TL;DR: This review focuses on what mammalian in vivo models and patient studies have taught us in the last 10 years about the transcription factor p63 and its different isoforms.

TL;DR: Consensus was achieved for inclusion of symptoms, physician-assessed clinical signs, and a measurement for long-term control of flares in the core set of outcome domains for eczema trials.

TL;DR: Heterogeneous activation states of TAMs in SCC are supported, and it is suggested that a dynamic model of macrophage activation would be more useful to characterize TAMs.

TL;DR: It is demonstrated that heme oxygenase-1 was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2), and regulation of the Nrf2/HO-1 pathway can reduce H( 2)O-2)-induced oxidative damage in human melanocytes.

TL;DR: Clinical improvement of psoriasis by NB-UVB is linked to suppression of Th17 and type I and type II IFN signaling pathways, which are critical in the pathogenesis of the disease.