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David M. Sabatini

Researcher at Massachusetts Institute of Technology

Publications -  424
Citations -  155896

David M. Sabatini is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: mTORC1 & PI3K/AKT/mTOR pathway. The author has an hindex of 155, co-authored 413 publications receiving 135833 citations. Previous affiliations of David M. Sabatini include Broad Institute & Johns Hopkins University.

Papers
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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more
- 13 Apr 2012 - 
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
PatentDOI

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

David M. Sabatini, +1 more
- 27 Jan 2006 - 
TL;DR: In this paper, the rictor-mTOR complex was used to identify compounds which modulate Akt activity mediated by the Rictor mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activation.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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mTOR Signaling in Growth, Metabolism, and Disease.

Robert A. Saxton, +1 more
- 09 Mar 2017 - 
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.