G
Graciela Kunrath Lima
Researcher at Universidade Federal de Minas Gerais
Publications - 20
Citations - 410
Graciela Kunrath Lima is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Encephalitis & Immune system. The author has an hindex of 9, co-authored 19 publications receiving 355 citations. Previous affiliations of Graciela Kunrath Lima include Oswaldo Cruz Foundation.
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Journal ArticleDOI
Toll-like receptor (TLR) 2 and TLR9 expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1 infection.
Graciela Kunrath Lima,Guilherme Pimenta Zolini,Daniel S. Mansur,Braulio H.F. Lima,Uschi Wischhoff,Ruiz G. Astigarraga,Marcela França Dias,Mariana das Graças Almeida Silva,Samantha Ribeiro Béla,Lis Ribeiro do Valle Antonelli,Rosa Maria Esteves Arantes,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,André Báfica,Erna Geessien Kroon,Marco Antônio Campos +16 more
TL;DR: It is hypothesize that HSV-1 infection is controlled by TLR-dependent immune responses in the TG, which prevent HSv-1 encephalitis, and that TLR2/9-/- mice were more susceptible to the virus.
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Immune response of calves vaccinated with Brucella abortus S19 or RB51 and revaccinated with RB51
Elaine Maria Seles Dorneles,Graciela Kunrath Lima,Andréa Teixeira-Carvalho,Márcio Sobreira Silva Araújo,Olindo Assis Martins-Filho,Nammalwar Sriranganathan,Hamzeh Al Qublan,Marcos Bryan Heinemann,Andrey Pereira Lage +8 more
TL;DR: In this paper, the authors compared the immune responses induced in cattle prime-immunized with B. abortus S19 or RB51 and revaccinated with RB51.
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The Chemokine CCL5 Is Essential for Leukocyte Recruitment in a Model of Severe Herpes simplex Encephalitis
Márcia Carvalho Vilela,Daniel S. Mansur,Norinne Lacerda-Queiroz,David Henrique Rodrigues,Graciela Kunrath Lima,Rosa Maria Esteves Arantes,Erna Geessien Kroon,Marco Antônio Campos,Mauro M. Teixeira,Antônio Lúcio Teixeira +9 more
TL;DR: CCL5, a chemokine that binds to CCR1 and CCR5, is essential for leukocyte adhesion during HSV‐1 encephalitis, however, blocking of C CR1 andCCR5 did not affect HSV-1 replication, suggesting that other immune mechanisms are involved in the process of infection control.
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Defense against HSV-1 in a murine model is mediated by iNOS and orchestrated by the activation of TLR2 and TLR9 in trigeminal ganglia
Guilherme Pimenta Zolini,Graciela Kunrath Lima,Natália Lucinda,Mariana das Graças Almeida Silva,Marcela França Dias,Natalia Lima Pessoa,Bruna Pizziolo Coura,Christiane Teixeira Cartelle,Rosa Maria Esteves Arantes,Erna Geessien Kroon,Marco Antônio Campos +10 more
TL;DR: TLRs efficiently orchestrate the innate immune cells, eliciting macrophage response (with NO production by the macrophages), thereby controlling the HSV-1 infection through the immune response in the TG of mice.
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Dendritic cells, macrophages, NK and CD8 + T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B
Natália Lucinda,Maria Marta Figueiredo,Natalia Lima Pessoa,Beatriz Senra Álvares da Silva Santos,Graciela Kunrath Lima,Arthur Molinari Freitas,Alexandre V. Machado,Erna Geessien Kroon,Lis Ribeiro do Valle Antonelli,Marco Antônio Campos +9 more
TL;DR: The data provide strong evidence that the responses mediated by DCs, Mo/Mϕ, NK and CD8+ T lymphocytes through IL-1β, iNOS and granzyme B production, respectively, together with the production of type I IFN early in the infection, are crucial to host defense against HSV-1.