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André Báfica
Researcher at Universidade Federal de Santa Catarina
Publications - 78
Citations - 4816
André Báfica is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Mycobacterium tuberculosis & Immune system. The author has an hindex of 34, co-authored 72 publications receiving 4456 citations. Previous affiliations of André Báfica include Oswaldo Cruz Foundation & National Institutes of Health.
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TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
TL;DR: A previously unappreciated role for TLR9 is revealed in the host response to M. tuberculosis and TLR collaboration in host resistance to a major human pathogen is illustrated.
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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent.
Fabiana S. Machado,James E. Johndrow,Lisia Esper,Alexandra Dias,André Báfica,Charles N. Serhan,Julio Aliberti +6 more
TL;DR: It is shown that lipoxins activate two receptors in DCs, AhR and LXAR, and that this activation triggers expression of suppressor of cytokine signaling (SOCS)-2, which is a crucial intracellular mediator of the anti-inflammatory actions of aspirin-inducedlipoxins in vivo.
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Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection.
André Báfica,Helton C. Santiago,Romina S. Goldszmid,Catherine Ropert,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Alan Sher +6 more
TL;DR: The results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and thatTLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-γ synthesis during infection with T. cruzi.
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Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
Lis Ribeiro do Valle Antonelli,Antonio Gigliotti Rothfuchs,Ricardo Gonçalves,Ester Roffê,Allen W. Cheever,André Báfica,Andres M. Salazar,Carl G. Feng,Alan Sher +8 more
TL;DR: The above findings suggest that Poly-ICLC treatment can detrimentally affect the outcome of M. tuberculosis infection, by promoting the accumulation of a permissive myeloid population in the lung.
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Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.
André Báfica,Charles A. Scanga,Charles N. Serhan,Fabiana S. Machado,Sandy White,Alan Sher,Julio Aliberti +6 more
TL;DR: It is demonstrated that lipoxins negatively regulate protective Th1 responses against mycobacterial infection in vivo and suggested that the inhibition of lipoxin biosynthesis could serve as a strategy for enhancing host resistance to M. tuberculosis.