M
Marco Antônio Campos
Researcher at Oswaldo Cruz Foundation
Publications - 52
Citations - 2855
Marco Antônio Campos is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 23, co-authored 50 publications receiving 2633 citations. Previous affiliations of Marco Antônio Campos include Universidade Federal de Minas Gerais & University of Würzburg.
Papers
More filters
Journal ArticleDOI
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Marco Antônio Campos,Igor C. Almeida,Osamu Takeuchi,Shizuo Akira,Eneida P. Valente,Daniela O. Procópio,Luiz R. Travassos,Jason A. Smith,Douglas T. Golenbock,Ricardo T. Gazzinelli +9 more
TL;DR: Evidence is presented that Trypanosoma cruzi-derived GPI anchors and GIPLs trigger CD25 expression on Chinese hamster ovary-K1 cells transfected with CD14 and Toll-like receptor-2 (TLR-2), but not wild-type (TLr-2-deficient) Chinese hamsters ovary cells, which may initiate host innate defense mechanisms and inflammatory response during protozoan infection.
Journal ArticleDOI
Activation of TLR2 and TLR4 by Glycosylphosphatidylinositols Derived from Toxoplasma gondii
Françoise Debierre-Grockiego,Marco Antônio Campos,Nahid Azzouz,Jörg C. Schmidt,Ulrike Bieker,Marianne Garcia Resende,Daniel S. Mansur,Ralf Weingart,Richard R. Schmidt,Douglas T. Golenbock,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Ralph T. Schwarz,Ralph T. Schwarz +14 more
TL;DR: Both TLR2 and TLR4 receptors may participate in the host defense against T. gondii infection through their activation by the GPIs and could work together with other MyD88-dependent receptors, like other TLRs or even IL-18R or IL-1R, to obtain an effective host response against the parasite.
Journal ArticleDOI
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
Ana Carolina Oliveira,Jaqueline R. Peixoto,Luciana Barros de Arruda,Marco Antônio Campos,Ricardo T. Gazzinelli,Douglas T. Golenbock,Shizuo Akira,José O. Previato,Lucia Mendonça-Previato,Alberto Nobrega,Maria Bellio +10 more
TL;DR: The results demonstrate that natural resistance to T. cruzi is TLR4 dependent, most likely due toTLR4 recognition of their GIPLs, and find that TLR 4-mutant mice were hypersusceptible to the infection, as evidenced by a higher parasitemia and earlier mortality.
Journal ArticleDOI
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
Marco Antônio Campos,Meire Closel,Eneida P. Valente,Jarbas E. Cardoso,Shizuo Akira,Jacqueline I. Alvarez-Leite,Catherine Ropert,Ricardo T. Gazzinelli +7 more
TL;DR: The results indicate that T.cruzi parasites elicit an alternative inflammatory pathway independent of TLR2 that is partially dependent on MyD88 and necessary for mounting optimal inflammatory and RNI responses that control T. cruzi replication during the early stages of infection.
Journal ArticleDOI
Role of Toll-Like Receptor 4 in Induction of Cell-Mediated Immunity and Resistance to Brucella abortus Infection in Mice
Marco Antônio Campos,Marco Antônio Campos,Gracia M. S. Rosinha,Gracia M. S. Rosinha,Igor C. Almeida,Xirlene S. Salgueiro,Bruce W. Jarvis,Gary A. Splitter,Nilofer Qureshi,Oscar Bruna-Romero,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Sergio C. Oliveira +12 more
TL;DR: Results indicate that TLR4 plays a role in resistance to B. abortus infection and that S lipid A has potent adjuvant activity.