Grantley R. Peck

TL;DR: Three hypotheses for the memory-potentiating effects of the AT(4) receptor/IRAP ligands, Ang IV and LVV-hemorphin 7, are proposed: acting as potent inhibitors of IRAP, they may prolong the action of endogenous promnestic peptides, and they may modulate glucose uptake by modulating trafficking of GLUT4.

TL;DR: In this paper, three hypotheses for the memory-potentiating effects of the AT4 receptor/IRAP ligands, Ang IV and LVV-hemorphin 7, are proposed: (i) acting as potent inhibitors of IRAP, they may prolong the action of endogenous promnestic peptides; (ii) they may modulate glucose uptake by modulating trafficking of GLUT4; (iii) IRAP may act as a receptor, transducing the signal initiated by ligand binding to its C-terminal domain to the intracellular domain that interacts

TL;DR: This study identifies a novel interaction between the amino terminus of IRAP and the Akt substrate, AS160 (Akt substrate of 160 kDa), and hypothesizes that AS160 is localized to GLUT4-containing vesicles via its interaction with IRAP where it inhibits the activity of Rab substrates in its vicinity, effectively tethering the vesicle intracellularly.

TL;DR: Insulin-regulated aminopeptidase was identified as the specific binding site for angiotensin IV, and it is proposed that it mediates the memory-enhancing effects of the peptide.

TL;DR: Central administration of Ang IV or LVV-hemorphin 7 (LVV-H7) markedly enhances learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia.