G
Graziella Cappelletti
Researcher at University of Milan
Publications - 76
Citations - 2022
Graziella Cappelletti is an academic researcher from University of Milan. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 25, co-authored 70 publications receiving 1731 citations.
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Journal ArticleDOI
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
Augusto Pessina,Arianna Bonomi,Valentina Coccè,Gloria Invernici,Stefania Elena Navone,Loredana Cavicchini,Francesca Sisto,Maura Ferrari,Lucia Viganò,Alberta Locatelli,Emilio Ciusani,Graziella Cappelletti,Daniele Cartelli,Caruso Arnaldo,Eugenio Parati,Giovanni Marfia,Roberto Pallini,Maria Laura Falchetti,Giulio Alessandri +18 more
TL;DR: These data demonstrate, for the first time, that without any genetic manipulation, mesenchymal stromal cells can uptake and subsequently slowly release PTX, which may lead to potential new tools to increase efficacy of cancer therapy.
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Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration
Daniele Cartelli,Cristina L. Ronchi,M.G. Maggioni,Simona Rodighiero,Erminio Giavini,Graziella Cappelletti +5 more
TL;DR: In this article, the microtubule (MT) system was found to be significantly deregulated following exposure to 1-methyl-4-phenylpiridinium (MPP) and a reorientation of MTs.
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Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective
Daniele Cartelli,Francesca Casagrande,Carla L. Busceti,Domenico Bucci,Gemma Molinaro,Anna Traficante,Daniele Passarella,Erminio Giavini,Gianni Pezzoli,Giuseppe Battaglia,Graziella Cappelletti +10 more
TL;DR: In this paper, the role of microtubule dysfunction in Parkinson's disease was examined in C57Bl mice and the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to precede axonal transport impairment and neurite degeneration.
Journal ArticleDOI
The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor.
TL;DR: This paper provides the first evidence that dynamic instability of microtubules is specifically affected by MPP+ and suggests that it could play a role in neuronal cell death underlying Parkinson's disease.
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Pleiotropic effects of spastin on neurite growth depending on expression levels
Elena Riano,Monica Martignoni,Giuseppe Mancuso,Daniele Cartelli,F. Crippa,Irene Toldo,Gabriele Siciliano,Daniela Di Bella,Franco Taroni,Maria Teresa Bassi,Graziella Cappelletti,Elena I. Rugarli +11 more
TL;DR: The study reveals that SPG4 is a dosage‐sensitive gene, and broadens the understanding of the role of spastin in neurite growth and MT dynamics, and supports haploinsufficiency as the molecular cause of the disease.