G
Gregory M Fomovsky
Researcher at Brigham and Women's Hospital
Publications - 4
Citations - 202
Gregory M Fomovsky is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Glucose transporter & Glucose uptake. The author has an hindex of 3, co-authored 4 publications receiving 161 citations.
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Journal ArticleDOI
Transcriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration
Caitlin C. O'Meara,Joseph A. Wamstad,Rachel Gladstone,Gregory M Fomovsky,Vincent L. Butty,Avanti Shrikumar,Joseph Gannon,Laurie A. Boyer,Richard T. Lee +8 more
TL;DR: In this paper, the authors derived a core transcriptional signature of injury-induced cardiac myocyte regeneration in mouse by comparing global transcriptional programs in a dynamic model of in vitro and in vivo CM differentiation, in vitro CM explant model, as well as a neonatal heart resection model.
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Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis
Jianming Jiang,Patrick G. Burgon,Hiroko Wakimoto,Kenji Onoue,Joshua M. Gorham,Caitlin C. O'Meara,Gregory M Fomovsky,Bradley K. McConnell,Richard T. Lee,Jonathan G. Seidman,Christine E. Seidman +10 more
TL;DR: It is suggested that human patients with homozygous MYBPC3-null mutations develop dilated cardiomyopathy, coupled with myocyte hyperplasia (increased cell number), as observed in Mybpct/t mice.
Journal ArticleDOI
Deletion of thioredoxin-interacting protein improves cardiac inotropic reserve in the streptozotocin-induced diabetic heart
Ronald B Myers,Gregory M Fomovsky,Samuel Lee,Max Tan,Bing F. Wang,Parth Patwari,Jun Yoshioka +6 more
TL;DR: Novel evidence is provided that hyperglycemia-induced Txnip is responsible for impaired cardiac inotropic reserve by direct regulation of insulin-independent glucose uptake through GLUT1 and plays a role in the development of diabetic cardiomyopathy.
Journal ArticleDOI
Abstract 108: Thioredoxin-interacting Protein Interacts with Glucose Transporters to Regulate Cardiac Glucose Metabolism
TL;DR: A novel link between GLUTs and Txnip is provided and this work demonstrates a fundamental regulatory mechanism of glucose homeostasis in the heart, directing cardiomyocyte towards enhanced functional reserve under diabetic conditions.