J
Jonathan G. Seidman
Researcher at Harvard University
Publications - 597
Citations - 104873
Jonathan G. Seidman is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Hypertrophic cardiomyopathy. The author has an hindex of 137, co-authored 563 publications receiving 89782 citations. Previous affiliations of Jonathan G. Seidman include Albert Einstein College of Medicine & Rutgers University.
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Journal ArticleDOI
Comprehensive molecular characterization of human colon and rectal cancer
Donna M. Muzny,Matthew N. Bainbridge,Kyle Chang,Huyen Dinh,Jennifer Drummond,Gerald R. Fowler,Christie Kovar,Lora Lewis,Margaret Morgan,Irene Newsham,Jeffrey G. Reid,Jireh Santibanez,Eve Shinbrot,Lisa R. Trevino,Yuan Qing Wu,Min Wang,Preethi H. Gunaratne,Preethi H. Gunaratne,Lawrence A. Donehower,Chad J. Creighton,David A. Wheeler,Richard A. Gibbs,Michael S. Lawrence,Douglas Voet,Rui Jing,Kristian Cibulskis,Andrey Sivachenko,Andrey Sivachenko,Petar Stojanov,Aaron McKenna,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Li Ding,Robert S. Fulton,Daniel C. Koboldt,Todd Wylie,Jason Walker,David J. Dooling,Lucinda Fulton,Kim D. Delehaunty,Catrina Fronick,Ryan Demeter,Elaine R. Mardis,Richard K. Wilson,Andy Chu,Hye Jung E. Chun,Andrew J. Mungall,Erin Pleasance,A. Gordon Robertson,Dominik Stoll,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Eric Chuah,Robin J.N. Coope,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Martin Hirst,Robert A. Holt,Darlene Lee,Haiyan I. Li,Michael Mayo,Richard A. Moore,Jacqueline E. Schein,Jared R. Slobodan,Angela Tam,Nina Thiessen,Richard Varhol,Thomas Zeng,Yongjun Zhao,Steven J.M. Jones,Marco A. Marra,Adam J. Bass,Alex H. Ramos,Gordon Saksena,Andrew D. Cherniack,Stephen E. Schumacher,Barbara Tabak,Scott L. Carter,Nam Pho,Huy V. Nguyen,Robert C. Onofrio,Andrew Crenshaw,Kristin G. Ardlie,Rameen Beroukhim,Wendy Winckler,Matthew Meyerson,Alexei Protopopov,Angela Hadjipanayis,Eunjung Lee,Ruibin Xi,Lixing Yang,Xiaojia Ren,Narayanan Sathiamoorthy,Peng Chieh Chen,Psalm Haseley,Yonghong Xiao,Semin Lee,Jonathan G. Seidman,Lynda Chin,Peter J. Park,Raju Kucherlapati,J. Todd Auman,Katherine A. Hoadley,Ying Du,Matthew D. Wilkerson,Yan Shi,Christina Liquori,Shaowu Meng,Ling Li,Yidi J. Turman,Michael D. Topal,Donghui Tan,Scot Waring,Elizabeth Buda,Jesse Walsh,Corbin D. Jones,Piotr A. Mieczkowski,Darshan Singh,Junyuan Wu,Anisha Gulabani,Peter Dolina,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Matthew G. Soloway,Lisle E. Mose,Stuart R. Jefferys,Saianand Balu,Brian O'Connor,Jan F. Prins,Derek Y. Chiang,D. Neil Hayes,Charles M. Perou,Toshinori Hinoue,Daniel J. Weisenberger,Dennis T. Maglinte,Fei Pan,Benjamin P. Berman,David Van Den Berg,Hui Shen,Timothy J. Triche,Stephen B. Baylin,Peter W. Laird,Gad Getz,Michael S. Noble,Doug Voat,Nils Gehlenborg,Daniel DiCara,Juinhua Zhang,Hailei Zhang,Chang-Jiun Wu,Spring Yingchun Liu,Sachet A. Shukla,Lihua Zhou,Pei Lin,Richard W. Park,Marc Danie Nazaire,James A. Robinson,Helga Thorvaldsdottir,Jill P. Mesirov,Vesteinn Thorsson,Sheila Reynolds,Brady Bernard,Richard Kreisberg,Jake Lin,Lisa Iype,Ryan Bressler,Timo Erkkilä,Madhumati Gundapuneni,Yuexin Liu,Adam Norberg,Thomas Robinson,Da Yang,Wei Zhang,Ilya Shmulevich,Jorma J. de Ronde,Jorma J. de Ronde,Nikolaus Schultz,Ethan Cerami,Giovanni Ciriello,Arthur P. Goldberg,Benjamin Gross,Anders Jacobsen,Jianjiong Gao,Bogumil Kaczkowski,Rileen Sinha,B. Arman Aksoy,Yevgeniy Antipin,Boris Reva,Ronglai Shen,Barry S. Taylor,Marc Ladanyi,Chris Sander,Rehan Akbani,Nianxiang Zhang,Bradley M. Broom,Tod D. Casasent,Anna K. Unruh,Chris Wakefield,Stanley R. Hamilton,R. Craig Cason,Keith A. Baggerly,John N. Weinstein,David Haussler,Christopher C. Benz,Joshua M. Stuart,Stephen C. Benz,J. Zachary Sanborn,Charles J. Vaske,Jingchun Zhu,Christopher Szeto,Gary K. Scott,Christina Yau,Sam Ng,Theodore C. Goldstein,Kyle Ellrott,Eric A. Collisson,Aaron E. Cozen,Daniel R. Zerbino,Christopher Wilks,Brian Craft,Paul T. Spellman,Robert Penny,Troy Shelton,Martha Hatfield,Scott Morris,Peggy Yena,Candace Shelton,Mark Sherman,Joseph Paulauskis,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Jay Bowen,Nilsa C. Ramirez,Nilsa C. Ramirez,Aaron D. Black,Robert E. Pyatt,Robert E. Pyatt,Lisa Wise,Peter White,Peter White,Monica M. Bertagnolli,Jen Brown,Timothy A. Chan,Gerald C. Chu,Christine Czerwinski,Fred Denstman,Rajiv Dhir,Arnulf Dörner,Charles S. Fuchs,Jose G. Guillem,Mary Iacocca,Hartmut Juhl,Andrew Kaufman,Bernard Kohl,Xuan Van Le,Maria C. Mariano,Elizabeth N. Medina,Michael Meyers,Garrett M. Nash,P. Paty,Nicholas J. Petrelli,Brenda Rabeno,William G. Richards,David B. Solit,Pat Swanson,Larissa K. Temple,Joel E. Tepper,Richard Thorp,Efsevia Vakiani,Martin R. Weiser,Joseph Willis,Gary Witkin,Zhaoshi Zeng,Michael J. Zinner,Carsten Zornig,Mark A. Jensen,Robert Sfeir,Ari B. Kahn,Anna L. Chu,Prachi Kothiyal,Zhining Wang,Eric E. Snyder,Joan Pontius,Todd Pihl,Brenda Ayala,Mark Backus,Jessica Walton,Jon Whitmore,Julien Baboud,Dominique L. Berton,Matthew C. Nicholls,Deepak Srinivasan,Rohini Raman,Stanley Girshik,Peter A. Kigonya,Shelley Alonso,Rashmi N. Sanbhadti,Sean P. Barletta,John M. Greene,David Pot,Kenna R. Mills Shaw,Laura A.L. Dillon,Kenneth H. Buetow,Tanja Davidsen,John A. Demchok,Greg Eley,Martin L. Ferguson,Peter Fielding,Carl F. Schaefer,Margi Sheth,Liming Yang,Mark S. Guyer,Bradley A. Ozenberger,Jacqueline D. Palchik,Jane Peterson,Heidi J. Sofia,Elizabeth J. Thomson +320 more
TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
The cancer genome atlas pan-cancer analysis project
John N. Weinstein,John N. Weinstein,Eric A. Collisson,Gordon B. Mills,Kenna R. Mills Shaw,Kenna R. Mills Shaw,Brad Ozenberger,Kyle Ellrott,Kyle Ellrott,Chris Sander,Joshua M. Stuart,Joshua M. Stuart,Kyle Chang,Chad J. Creighton,Caleb F. Davis,Lawrence A. Donehower,Jennifer Drummond,David A. Wheeler,Adrian Ally,Miruna Balasundaram,Inanc Birol,Inanc Birol,Inanc Birol,Yaron S.N. Butterfield,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Martin Hirst,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Richard Varhol,Rameen Beroukhim,Ami S. Bhatt,Angela N. Brooks,Andrew D. Cherniack,Samuel S. Freeman,Stacey Gabriel,Elena Helman,Joonil Jung,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Travis I. Zack,Eric S. Lander,Christopher A. Bristow,Angela Hadjipanayis,Psalm Haseley,Raju Kucherlapati,Semin Lee,Eunjung Lee,Lovelace J. Luquette,Harshad S. Mahadeshwar,Angeliki Pantazi,Michael Parfenov,Michael Parfenov,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Netty Santoso,Jonathan G. Seidman,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Ruibin Xi,Ruibin Xi,Andrew Wei Xu,Lixing Yang,Dong Zeng,J. Todd Auman,Saianand Balu,Elizabeth Buda,Cheng Fan,Katherine A. Hoadley,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Yan Shi,Grace O. Silva,Donghui Tan,Umadevi Veluvolu,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Wei Zhao,Tom Bodenheimer,D. Neil Hayes,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jeffreys,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Stephen B. Baylin,Benjamin P. Berman,Moiz S. Bootwalla,Ludmila Danilova,James G. Herman,Toshinori Hinoue,Peter W. Laird,Suhn K. Rhie,Hui Shen,Timothy J. Triche,Daniel J. Weisenberger,Scott L. Carter,Kristian Cibulskis,Lynda Chin,Jianhua Zhang,Carrie Sougnez,Min Wang,Gad Getz,Gad Getz,Huyen Dinh,Harshavardhan Doddapaneni,Richard A. Gibbs,Preethi Gunaratne,Preethi Gunaratne,Yi Han,Divya Kalra,Christie Kovar,Lora Lewis,Margaret B. Morgan,Donna Morton,Donna Muzny,Jeffrey G. Reid,Liu Xi,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Jaegil Kim,Michael S. Lawrence,Pei Lin,Yingchun Liu,Michael S. Noble,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Chip Stewart,Brady Bernard,Ryan Bressler,Andrea Eakin,Lisa Iype,Theo A. Knijnenburg,Roger Kramer,Richard Kreisberg,Kalle Leinonen,Jake Lin,Yuexin Liu,Michael Miller,Sheila M. Reynolds,Hector Rovira,Ilya Shmulevich,Vesteinn Thorsson,Da Yang,Wei Zhang,Samirkumar B. Amin,Chang-Jiun Wu,Chia Chin Wu,Rehan Akbani,Kenneth Aldape,Keith A. Baggerly,Bradley McIntosh Broom,Tod D. Casasent,James Cleland,Deepti Dodda,Mary Elizabeth Edgerton,Leng Han,Shelley M. Herbrich,Zhenlin Ju,Hoon Kim,Hoon Kim,Seth Lerner,Jun Li,Han Liang,Wenbin Liu,Philip L. Lorenzi,Yiling Lu,James M. Melott,Lam Nguyen,Lam Nguyen,Xiaoping Su,Roeland Verhaak,Wenyi Wang,Andrew J. Wong,Andrew J. Wong,Yang Yang,Jun Yao,Rong Yao,Kosuke Yoshihara,Yuan Yuan,Yuan Yuan,W. K. Alfred Yung,Nianxiang Zhang,Siyuan Zheng,Michael B. Ryan,Michael B. Ryan,David W. Kane,David W. Kane,B. Arman Aksoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,André Kahles,Marc Ladanyi,William Lee,Kjong-Van Lehmann,Martin L. Miller,Ricardo Ramirez,Gunnar Rätsch,Boris Reva,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Barry S. Taylor,Barry S. Taylor,Nils Weinhold,Suzanne S. Fei,Paul T. Spellman,Christopher C. Benz,Christopher C. Benz,Daniel E. Carlin,Daniel E. Carlin,Melisssa Cline,Melisssa Cline,Brian Craft,Brian Craft,Mary Goldman,David Haussler,David Haussler,David Haussler,Singer Ma,Singer Ma,Sam Ng,Sam Ng,Evan O. Paull,Evan O. Paull,Amie Radenbaugh,Amie Radenbaugh,Sofie R. Salama,Sofie R. Salama,Sofie R. Salama,Artem Sokolov,Artem Sokolov,Teresa Swatloski,Teresa Swatloski,Vladislav Uzunangelov,Vladislav Uzunangelov,Peter Waltman,Peter Waltman,Christina Yau,Jing Zhu,Jing Zhu,Stanley R. Hamilton,Scott Abbott,Rachel Abbott,Nathan D. Dees,Kim D. Delehaunty,Li Ding,David J. Dooling,James M. Eldred,Catrina Fronick,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Krishna L. Kanchi,Cyriac Kandoth,Daniel C. Koboldt,David E. Larson,Timothy J. Ley,Ling Lin,Charles Lu,Vincent Magrini,Elaine R. Mardis,Michael D. McLellan,Joshua F. McMichael,Christopher A. Miller,Michelle O'Laughlin,Craig Pohl,Heather Schmidt,Scott M. Smith,Jason Walker,John W. Wallis,Michael C. Wendl,Michael C. Wendl,Richard K. Wilson,Todd Wylie,Qunyuan Zhang,Robert A. Burton,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David A. Pot,Yunhu Wan,Douglas A. Levine,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Hollie A. Harper,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Nilsa C. Ramirez,Nilsa C. Ramirez,Samantha Sharpe,Lisa Wise,Erik Zmuda,Stephen J. Chanock,Tanja Davidsen,John A. Demchok,Greg Eley,Ina Felau,Margi Sheth,Heidi J. Sofia,Louis M. Staudt,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Larsson Omberg,Adam Margolin,Benjamin J. Raphael,Fabio Vandin,Hsin-Ta Wu,Mark D.M. Leiserson,Stephen C. Benz,Charles J. Vaske,Houtan Noushmehr,Houtan Noushmehr,Denise M. Wolf,Laura van 't Veer,Dimitris Anastassiou,Tai Hsien Ou Yang,Nuria Lopez-Bigas,Abel Gonzalez-Perez,David Tamborero,Zheng Xia,Wei Li,Dong Yeon Cho,Teresa M. Przytycka,Mark P. Hamilton,Sean E. McGuire,Sven Nelander,Sven Nelander,Patrik Johansson,Rebecka Jörnsten,Rebecka Jörnsten,Teresia Kling +379 more
TL;DR: The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA with a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages.
Journal Article
The Cancer Genome Atlas Pan-Cancer analysis project
Kyle Chang,Chad J Creighton,Caleb F. Davis,Lawrence A. Donehower,Jennifer Drummond,David A. Wheeler,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Martin Hirst,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Richard Varhol,Rameen Beroukhim,Ami S. Bhatt,Angela N. Brooks,Andrew D. Cherniack,Samuel S. Freeman,Stacey Gabriel,Elena Helman,Joonil Jung,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Eric S. Lander,Christopher A. Bristow,Angela Hadjipanayis,Psalm Haseley,Raju Kucherlapati,Semin Lee,Eunjung Lee,Lovelace J. Luquette,Harshad S. Mahadeshwar,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Netty Santoso,Jonathan G. Seidman,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Andrew Wei Xu,Lixing Yang,Dong Zeng,J. Todd Auman,Saianand Balu,Elizabeth Buda,Cheng Fan,Katherine A. Hoadley,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Yan Shi,Grace O. Silva,Donghui Tan,Umadevi Veluvolu,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Wei Zhao,Tom Bodenheimer,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jeffreys,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Stephen B. Baylin,Benjamin P. Berman,Moiz S. Bootwalla,Ludmila Danilova,James G. Herman,Toshinori Hinoue,Peter W. Laird,Suhn K. Rhie,Hui Shen,Timothy J. Triche,Daniel J. Weisenberger,Scott L. Carter,Kristian Cibulskis,Lynda Chin,Jianhua Zhang,Gad Getz,Carrie Sougnez,Min Wang,Huyen Dinh,Harshavardhan Doddapaneni,Richard A. Gibbs,Preethi H. Gunaratne,Yi Han,Divya Kalra,Christie Kovar,Lora Lewis,Margaret Morgan,Donna Morton,Donna M. Muzny,Jeffrey G. Reid,Liu Xi,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Jaegil Kim,Michael S. Lawrence,Pei Lin,Yingchun Liu,Michael S. Noble,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Chip Stewart,Brady Bernard,Ryan Bressler,Andrea Eakin,Lisa Iype,Theo A. Knijnenburg,Roger Kramer,Richard Kreisberg,Kalle Leinonen,Jake Lin,Yuexin Liu,Michael W. Miller,Sheila Reynolds,Hector Rovira,Ilya Shmulevich,Vesteinn Thorsson,Da Yang,Wei Zhang,Samirkumar B. Amin,Chang-Jiun Wu,Chia Chin Wu,Rehan Akbani,Kenneth Aldape,Keith A. Baggerly,Bradley M. Broom,Tod D. Casasent,James Cleland,Chad J. Creighton,Deepti Dodda,Mary E. Edgerton,Leng Han,Shelley M. Herbrich,Zhenlin Ju,Hoon Kim,Seth P. Lerner,Jun Li,Han Liang,Wen-Bin Liu,Philip L. Lorenzi,Yiling Lu,James M. Melott,Gordon B. Mills,Lam Nhat Nguyen,Xiaoping Su,Roeland Verhaak,Wenyi Wang,John N. Weinstein,Andrew Wong,Yang Yang,Jun Yao,Rong Yao,Kosuke Yoshihara,Yuan Yuan,Alfred K Yung,Nianxiang Zhang,Siyuan Zheng,Michael T. Ryan,David W. Kane,B. Arman Aksoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,André Kahles,Marc Ladanyi,William H. Lee,Kjong-Van Lehmann,Martin L. Miller,Ricardo Ramirez,Gunnar Rätsch,Boris Reva,Chris Sander,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Nils Weinhold,Suzanne S. Fei,Paul T. Spellman,Christopher C. Benz,Daniel E. Carlin,Melisssa Cline,Brian Craft,Kyle Ellrott,Mary Goldman,David Haussler,Singer Ma,Sam Ng,Evan O. Paull,Amie Radenbaugh,Sofie R. Salama,Artem Sokolov,Joshua M. Stuart,Teresa Swatloski,Vladislav Uzunangelov,Peter Waltman,Christina Yau,Jing Zhu,Stanley R. Hamilton,Scott Abbott,Rachel Abbott,Nathan D. Dees,Kim D. Delehaunty,Li Ding,David J. Dooling,James M. Eldred,Catrina Fronick,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Krishna-Latha Kanchi,Cyriac Kandoth,Daniel C. Koboldt,David E. Larson,Timothy J. Ley,Ling Lin,Charles Lu,Vincent Magrini,Elaine R. Mardis,Michael D. McLellan,Joshua F. McMichael,Christopher A. Miller,Michelle O'Laughlin,Craig Pohl,Heather Schmidt,Scott M. Smith,Jason Walker,John W. Wallis,Michael C. Wendl,Richard K. Wilson,Todd Wylie,Qunyuan Zhang,Robert A. Burton,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Yunhu Wan,Douglas A. Levine,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Hollie A. Harper,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Nilsa C. Ramirez,Samantha Sharpe,Lisa Wise,Erik Zmuda,Stephen J. Chanock,Tanja Davidsen,John A. Demchok,Greg Eley,Ina Felau,Brad Ozenberger,Margi Sheth,Heidi J. Sofia,Louis M. Staudt,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Larsson Omberg,Adam A. Margolin,Benjamin J. Raphael,Fabio Vandin,Hsin-Ta Wu,Mark D.M. Leiserson,Stephen C. Benz,Charles J. Vaske,Houtan Noushmehr,Denise M. Wolf,Laura van 't Veer,Eric A. Collisson,Dimitris Anastassiou,Tai-Hsien Ou Yang,Nuria Lopez-Bigas,Abel Gonzalez-Perez,David Tamborero,Zheng Xia,Wei Li,Dong-Yeon Cho,Teresa M. Przytycka,Mark P. Hamilton,Sean E. McGuire,Sven Nelander,Patrik Johansson,Rebecka Jörnsten,Teresia Kling,Jose Miguel Sanchez,Kenna R. Mills Shaw +337 more
TL;DR: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels as mentioned in this paper.
Journal ArticleDOI
Comprehensive molecular characterization of gastric adenocarcinoma
Adam J. Bass,Vesteinn Thorsson,Ilya Shmulevich,Sheila Reynolds,Michael Miller,Brady Bernard,Toshinori Hinoue,Peter W. Laird,Christina Curtis,Hui Shen,Daniel J. Weisenberger,Nikolaus Schultz,Ronglai Shen,Nils Weinhold,David P. Kelsen,Reanne Bowlby,Andy Chu,Katayoon Kasaian,Andrew J. Mungall,A. Gordon Robertson,Payal Sipahimalani,Andrew D. Cherniack,Gad Getz,Yingchun Liu,Michael S. Noble,Chandra Pedamallu,Carrie Sougnez,Amaro Taylor-Weiner,Rehan Akbani,Ju Seog Lee,Wenbin Liu,GB Mills,Da Yang,Wei Zhang,Angeliki Pantazi,Michael Parfenov,Margaret L. Gulley,M. Blanca Piazuelo,Barbara G. Schneider,Jihun Kim,Alex Boussioutas,Margi Sheth,John A. Demchok,Charles S. Rabkin,Joseph Willis,Sam Ng,Katherine S. Garman,David G. Beer,Arjun Pennathur,Benjamin J. Raphael,Hsin-Ta Wu,Robert D. Odze,Hark Kyun Kim,Jay Bowen,Kristen M. Leraas,Tara M. Lichtenberg,Stephanie Weaver,Michael D. McLellan,Maciej Wiznerowicz,Ryo Sakai,Michael S. Lawrence,Kristian Cibulskis,Lee Lichtenstein,Sheila Fisher,Stacey Gabriel,Eric S. Lander,Li Ding,Beifang Niu,Adrian Ally,Miruna Balasundaram,Inanc Birol,Denise Brooks,Yaron S.N. Butterfield,Rebecca Carlsen,Justin Chu,Eric Chuah,Hye Jung E. Chun,Amanda Clarke,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan A. Li,Emilia L. Lim,Yussanne Ma,Marco A. Marra,Michael Mayo,Richard A. Moore,Karen Mungall,Ka Ming Nip,Jacqueline E. Schein,Angela Tam,Nina Thiessen,Rameen Beroukhim,Scott L. Carter,Andrew D. Cherniack,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Joonil Jung,Jaegil Kim,Pei Lin,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Petar Stojanov,Barbara Tabak,Doug Voet,Mara Rosenberg,Travis I. Zack,Hailei Zhang,Lihua Zou,Alexei Protopopov,Netty Santoso,Semin Lee,Jianhua Zhang,Harshad S. Mahadeshwar,Jiabin Tang,Xiaojia Ren,Sahil Seth,Lixing Yang,Andrew Wei Xu,Xingzhi Song,Ruibin Xi,Christopher A. Bristow,Angela Hadjipanayis,Jonathan G. Seidman,Lynda Chin,Peter J. Park,Raju Kucherlapati,Shiyun Ling,Arvind Rao,John N. Weinstein,Sang Bae Kim,Yiling Lu,Gordon B. Mills,Moiz S. Bootwalla,Phillip H. Lai,Timothy J. Triche,David Van Den Berg,Stephen B. Baylin,James G. Herman,Bradley A. Murray,B. Arman Askoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,William Lee,Ricardo Ramirez,Chris Sander,Yasin Senbabaoglu,Rileen Sinha,S. Onur Sumer,Yichao Sun,Lisa Iype,Roger Kramer,Richard Kreisberg,Hector Rovira,Natalie Tasman,Santa Cruz Sam Ng,David Haussler,Josh Stuart,Roeland Verhaak,Mark D.M. Leiserson,Barry S. Taylor,Aaron D. Black,Julie Ann Carney,Julie M. Gastier-Foster,Carmen Helsel,Cynthia McAllister,Nilsa C. Ramirez,Teresa R. Tabler,Lisa Wise,Erik Zmuda,Robert Penny,Daniel Crain,Johanna Gardner,Kevin Lau,Erin Curely,David Mallery,Scott Morris,Joseph Paulauskis,Troy Shelton,Candace Shelton,Mark E. Sherman,Christopher C. Benz,Jae Hyuk Lee,Konstantin V. Fedosenko,Georgy Manikhas,Olga Potapova,Olga Voronina,Smitry Belyaev,Oleg Dolzhansky,W. Kimryn Rathmell,Jakub Brzezinski,Matthew Ibbs,Konstanty Korski,Witold Kycler,Radoslaw ŁaŸniak,Ewa Leporowska,Andrzej Mackiewicz,Dawid Murawa,Pawel Murawa,Arkadiusz Spychała,Wiktoria Maria Suchorska,Honorata Tatka,M. Teresiak,Raafat Abdel-Misih,Joseph J. Bennett,Jennifer Brown,Mary Iacocca,Brenda Rabeno,Sun Young Kwon,Ariane Kemkes,Erin Curley,Iakovina Alexopoulou,Jay Engel,John M. S. Bartlett,Monique Albert,Do-Youn Park,Rajiv Dhir,James D. Luketich,Rodney J. Landreneau,Yelena Y. Janjigian,Eunjung Cho,Marc Ladanyi,Laura H. Tang,Shannon J. McCall,Young Soo Park,Jae Ho Cheong,Jaffer A. Ajani,M. Constanza Camargo,Shelley Alonso,Brenda Ayala,Mark A. Jensen,Todd Pihl,Rohini Raman,Jessica Walton,Yunhu Wan,Greg Eley,Kenna R. Mills Shaw,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Tanja M. Davidsen,Carolyn M. Hutter,Heidi J. Sofia,Robert Burton,Sudha Chudamani,Jia Liu +257 more
TL;DR: A comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project is described and a molecular classification dividing gastric cancer into four subtypes is proposed.
Journal ArticleDOI
Comprehensive genomic characterization of head and neck squamous cell carcinomas
Michael S. Lawrence,Carrie Sougnez,Lee Lichtenstein,Kristian Cibulskis,Eric S. Lander,Stacey Gabriel,Gad Getz,Adrian Ally,Miruna Balasundaram,Inanc Birol,Reanne Bowlby,Denise Brooks,Yaron S.N. Butterfield,Rebecca Carlsen,Dean Cheng,Andy Chu,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Alexei Protopopov,Netty Santoso,Semin Lee,Michael Parfenov,Jianhua Zhang,Harshad S. Mahadeshwar,Jiabin Tang,Xiaojia Ren,Sahil Seth,Psalm Haseley,Dong Zeng,Lixing Yang,Andrew Wei Xu,Xingzhi Song,Angeliki Pantazi,Christopher A. Bristow,Angela Hadjipanayis,Jonathan G. Seidman,Lynda Chin,Peter J. Park,Raju Kucherlapati,Rehan Akbani,Tod D. Casasent,Wenbin Liu,Yiling Lu,Gordon B. Mills,Thomas C. Motter,John N. Weinstein,Lixia Diao,Jing Wang,You Hong Fan,Jinze Liu,Kai Wang,J. Todd Auman,Saianand Balu,Thomas Bodenheimer,Elizabeth Buda,D. Neil Hayes,Katherine A. Hoadley,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Patrick K. Kimes,Yufeng Liu,James Stephen Marron,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Joel S. Parker,Charles M. Perou,Jan F. Prins,Jeffrey Roach,Yan Shi,Janae V. Simons,Darshan Singh,Matthew G. Soloway,Donghui Tan,Umadevi Veluvolu,Vonn Walter,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Ni Zhao,Andrew D. Cherniack,Peter S. Hammerman,Aaron D. Tward,Chandra Sekhar Pedamallu,Gordon Saksena,Joonil Jung,Akinyemi I. Ojesina,Scott L. Carter,Travis I. Zack,Steven E. Schumacher,Rameen Beroukhim,Samuel S. Freeman,Matthew Meyerson,Juok Cho,Michael S. Noble,Daniel DiCara,Hailei Zhang,David I. Heiman,Nils Gehlenborg,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Donna M. Muzny,Harshavardhan Doddapaneni,Christie Kovar,Jeffrey S. Reid,Donna Morton,Yi Han,Walker Hale,Hsu Chao,Kyle Chang,Jennifer Drummond,Richard A. Gibbs,Nipun Kakkar,David A. Wheeler,Liu Xi,Giovanni Ciriello,Marc Ladanyi,William Lee,Ricardo Ramirez,Chris Sander,Ronglai Shen,Rileen Sinha,Nils Weinhold,Barry S. Taylor,B. Arman Aksoy,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,Boris Reva,Nikolaus Schultz,S. Onur Sumer,Yichao Sun,Timothy A. Chan,Luc G. T. Morris,Joshua M. Stuart,Stephen C. Benz,Sam Ng,Christopher C. Benz,Christina Yau,Stephen B. Baylin,Leslie Cope,Ludmila Danilova,James G. Herman,Moiz S. Bootwalla,Dennis T. Maglinte,Peter W. Laird,Timothy J. Triche,Daniel J. Weisenberger,David Van Den Berg,Nishant Agrawal,Justin A. Bishop,Paul C. Boutros,Jeff Bruce,Lauren Averett Byers,Joseph A. Califano,Thomas E. Carey,Zhong Chen,Hui Cheng,Simion I. Chiosea,Ezra E.W. Cohen,Brenda Diergaarde,Ann Marie Egloff,Adel K. El-Naggar,Robert L. Ferris,Mitchell J. Frederick,Jennifer R. Grandis,Yan Guo,Robert I. Haddad,Thomas M. Harris,Angela B.Y. Hui,J. Jack Lee,Scott M. Lippman,Fei-Fei Liu,Jonathan B. McHugh,Jeffrey N. Myers,Patrick Kwok Shing Ng,Bayardo Perez-Ordonez,Curtis R. Pickering,Michael B. Prystowsky,Marjorie Romkes,Anthony Saleh,Maureen A. Sartor,Raja R. Seethala,Tanguy Y. Seiwert,Han Si,Carter Van Waes,Daryl Waggott,Maciej Wiznerowicz,Wendell G. Yarbrough,Jiexin Zhang,Zhixiang Zuo,Ken Burnett,Daniel Crain,Johanna Gardner,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,Troy Shelton,Mark E. Sherman,Peggy Yena,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Hollie A. Harper,Kristen M. Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Lisa Wise,Erik Zmuda,Julien Baboud,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Robert A. Burton,Tanja Davidsen,John A. Demchok,Greg Eley,Martin L. Ferguson,Kenna R. Mills Shaw,Bradley A. Ozenberger,Margi Sheth,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Charles Saller,Katherine Tarvin,Chu Chen,Roni J. Bollag,Paul M. Weinberger,Wojciech Golusiński,Paweł Golusiński,Matthew Ibbs,Konstanty Korski,Andrzej Mackiewicz,Wiktoria Maria Suchorska,Bartosz Szybiak,Erin Curley,Christina Beard,Colleen Mitchell,George E. Sandusky,Julie Ahn,Zubair Khan,Jonathan C. Irish,John Waldron,William N. William,Sophie C. Egea,Carmen Gomez-Fernandez,Lynn M. Herbert,Carol R. Bradford,Douglas B. Chepeha,Andrea Haddad,Tamara R. Jones,Christine M. Komarck,Mayya Malakh,Jeffrey S. Moyer,Ariane Nguyen,Lisa A. Peterson,Mark E. Prince,Laura S. Rozek,Evan G. Taylor,Heather M. Walline,Gregory T. Wolf,Lori Boice,Bhishamjit S. Chera,William K. Funkhouser,Margaret L. Gulley,Trevor Hackman,Michele C. Hayward,Mei Huang,W. Kimryn Rathmell,Ashley H. Salazar,William W. Shockley,Carol G. Shores,Leigh B. Thorne,Mark C. Weissler,Sylvia Wrenn,Adam M. Zanation,Brandee T. Brown,Michelle Q. Pham +309 more
TL;DR: It is shown that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1.