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Guan-Dong Shang

Researcher at Chinese Academy of Sciences

Publications -  11
Citations -  454

Guan-Dong Shang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Chromatin. The author has an hindex of 3, co-authored 6 publications receiving 200 citations. Previous affiliations of Guan-Dong Shang include Center for Excellence in Education.

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A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root.

TL;DR: This study finds that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes and identifies the expression signatures of intermediate states during root cell differentiation at single-cell resolution.
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AP2/ERF Transcription Factors Integrate Age and Wound Signals for Root Regeneration.

TL;DR: It is shown that the increased levels of three closely-related miR156-targeted Arabidopsis (Arabidopsis thaliana) SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, SPL2, SPL10, and SPL11, suppress root regeneration with age by inhibiting wound-induced auxin biosynthesis.
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Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis.

TL;DR: It is shown that auxin rapidly rewires the cell totipotency network by altering chromatin accessibility, which reveals a hierarchical gene regulatory network underlying somatic embryogenesis and establishes a direct link betweencell totipotent genes and the embryonic development pathway.
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Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration.

TL;DR: In this paper , the authors investigated the role of auxin/cytokinin ratio in shoot regeneration in Arabidopsis shoot regeneration and found that a high auxin ratio environment primes shoot regeneration by increasing the accessibility of gene loci associated with pluripotency.
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Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis .

TL;DR: In this article, it was shown that the rate of decline in miR156 is correlated with developmental age rather than chronological age, which suggests that cell quiescence is the fountain of youth in plants.