G
Guan Wang
Researcher at Chinese Academy of Sciences
Publications - 15
Citations - 213
Guan Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Halogen bond & Protein ligand. The author has an hindex of 6, co-authored 15 publications receiving 191 citations.
Papers
More filters
Journal ArticleDOI
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors
Zhijian Xu,Zheng Liu,Tong Chen,Tiantian Chen,Zhen Wang,Guanghui Tian,Jing Shi,Xuelan Wang,Yunxiang Lu,Xiuhua Yan,Guan Wang,Hualiang Jiang,Kaixian Chen,Shudong Wang,Yechun Xu,Jingshan Shen,Weiliang Zhu +16 more
TL;DR: X-ray crystal structures verified the existence of the predicted halogen bonds, demonstrating that the halogen bond is an applicable tool in drug design and should be routinely considered in lead optimization.
Journal ArticleDOI
Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.
Jing Ren,Yang He,Wuyan Chen,Tiantian Chen,Guan Wang,Zhen Wang,Zhijian Xu,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Jingshan Shen,Yechun Xu +11 more
TL;DR: The first comprehensive thermodynamic and structural characterization of halogen bonding in PDE5-inhibitor interactions is presented, revealing that binding strength of the halogen bonded between chlorine, bromine, and iodine of inhibitor and the protein is -1.57 kJ/mol.
Journal ArticleDOI
Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5
Guan Wang,Zheng Liu,Tiantian Chen,Zhen Wang,Huaiyu Yang,Mingyue Zheng,Jing Ren,Guanghui Tian,Xiaojun Yang,Li Li,Jianfeng Li,Jin Suo,Rongxia Zhang,Xiangrui Jiang,Nicholas K. Terrett,Jingshan Shen,Yechun Xu,Hualiang Jiang +17 more
TL;DR: A series of novel PDE5 inhibitors with the new scaffold of the monocyclic pyrimidin-4(3H)-one ring developed using the structure-based discovery strategy are reported, including the most potent compound, which has an excellent IC50 in vitro and a good efficacy in a rat model of erection.
Journal ArticleDOI
Comparison of ionospheric F2 peak parameters foF2 and hmF2 with IRI2001 at Hainan
TL;DR: In this paper, the authors used the DPS4 digisonde at Hainan (19.5°N, 109.1°E) to investigate the low-latitude ionospheric variations and compare with the International Reference Ionosphere (IRI) model predictions.
Journal ArticleDOI
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Xudong Gong,Guan Wang,Jing Ren,Zheng Liu,Zhen Wang,Tiantian Chen,Xiaojun Yang,Xiangrui Jiang,Jingshan Shen,Hualiang Jiang,Haji Akber Aisa,Yechun Xu,Jianfeng Li +12 more
TL;DR: There is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM).